Transcription Factor

						

			
Accessions: NFKB2_DBD (HumanTF 1.0)

			
Names: DNA-binding factor KBF2, H2TF1, Lymphocyte translocation chromosome 10 protein, Lyt10, NFKB2, NFKB2_HUMAN, Nuclear factor NF-kappa-B p100 subunit, Nuclear factor of kappa light polypeptide gene enhancer in B-cells 2, Oncogene Lyt-10
Organisms: Homo sapiens
Libraries: HumanTF 1.0 1
1 Jolma A, Yan J, Whitington T, Toivonen J, Nitta KR, Rastas P, Morgunova E, Enge M, Taipale M, Wei G, Palin K, Vaquerizas JM, Vincentelli R, Luscombe NM, Hughes TR, Lemaire P, Ukkonen E, Kivioja T, Taipale J. DNA-Binding Specificities of Human Transcription Factors. Cell. 2013 Jan 17;152(1-2):327-39. [Pubmed]
Uniprot: Q00653
Notes: Ensembl ID: ENSG00000077150; DNA-binding domain sequence; TF family: NFAT; Clone source: MGC
Length: 334
Pfam Domains:    26-206 Rel homology domain (RHD)
Sequence: 
(in bold interface residues)		   1 MADFKLNSSIVEPKEPAPETADGPYLVIVEQPKQRGFRFRYGCEGPSHGGLPGASSEKGR   60
  61 KTYPTVKICNYEGPAKIEVDLVTHSDPPRAHAHSLVGKQCSELGICAVSVGPKDMTAQFN  120
 121 NLGVLHVTKKNMMGTMIQKLQRQRLRSRPQGLTEAEQRELEQEAKELKKVMDLSIVRLRF  180
 181 SAFLRASDGSFSLPLKPVISQPIHDSKSPGASNLKISRMDKTAGSVRGGDEVYLLCDKVQ  240
 241 KDDIEVRFYEDDENGWQAFGDFSPTDVHKQYAIVFRTPPYHKMKIERPVTVFLQLKRKRG  300
 301 GDVSDSKQFTYYPLVEDKEEVQRKRRKALPTFSQ
Interface Residues: 38, 40, 41, 43, 44, 46, 47, 48, 207, 209, 238, 269
3D-footprint Homologues: 1gji_A, 2ram_A, 1imh_C, 7cli_B, 1nfk_A, 1a3q_A, 2o61_A
Binding Motifs: NFKB2_DBD aGGGGAwTCCCCy
			
Publications: Jolma A, Yan J, Whitington T, Toivonen J, Nitta KR, Rastas P, Morgunova E, Enge M, Taipale M, Wei G, Palin K, Vaquerizas JM, Vincentelli R, Luscombe NM, Hughes TR, Lemaire P, Ukkonen E, Kivioja T, Taipale J. DNA-Binding Specificities of Human Transcription Factors. Cell. 2013 Jan 17;152(1-2):327-39. [Pubmed]
Related annotations: PaperBLAST

	
			


			

				

				
				
				
				

			

			

		

	
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