Transcription Factor
| Accessions: | PBX2_HUMAN (HOCOMOCO 10), P40425 (JASPAR 2024) |
| Names: | Homeobox protein PBX2, PBX2_HUMAN, Pre-B-cell leukemia transcription factor 2, Protein G17 |
| Organisms: | Homo sapiens |
| Libraries: | HOCOMOCO 10 1, JASPAR 2024 2 1 Kulakovskiy IV, Vorontsov IE, Yevshin IS, Soboleva AV, Kasianov AS, Ashoor H, Ba-Alawi W, Bajic VB, Medvedeva YA, Kolpakov FA, Makeev VJ. HOCOMOCO: expansion and enhancement of the collection of transcription factor binding sites models. Nucleic Acids Res : (2016). [Pubmed] 2 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed] |
| Length: | 430 |
| Pfam Domains: | 50-243 PBC domain 245-304 Homeobox domain 263-301 Homeobox KN domain |
| Sequence: (in bold interface residues) | 1 MDERLLGPPPPGGGRGGLGLVSGEPGGPGEPPGGGDPGGGSGGVPGGRGKQDIGDILQQI 60 61 MTITDQSLDEAQAKKHALNCHRMKPALFSVLCEIKEKTGLSIRSSQEEEPVDPQLMRLDN 120 121 MLLAEGVAGPEKGGGSAAAAAAAAASGGGVSPDNSIEHSDYRSKLAQIRHIYHSELEKYE 180 181 QACNEFTTHVMNLLREQSRTRPVAPKEMERMVSIIHRKFSAIQMQLKQSTCEAVMILRSR 240 241 FLDARRKRRNFSKQATEVLNEYFYSHLSNPYPSEEAKEELAKKCGITVSQVSNWFGNKRI 300 301 RYKKNIGKFQEEANIYAVKTAVSVTQGGHSRTSSPTPPSSAGSGGSFNLSGSGDMFLGMP 360 361 GLNGDSYSASQVESLRHSMGPGGYGDNLGGGQMYSPREMRANGSWQEAVTPSSVTSPTEG 420 421 PGSVHSDTSN |
| Interface Residues: | 212, 213, 214, 217, 218, 224, 227, 228, 231, 245, 246, 247, 248, 249, 289, 290, 292, 293, 296, 297, 300, 301, 304 |
| 3D-footprint Homologues: | 1au7_A, 8g87_X, 1e3o_C, 5zfz_A, 6fqp_B, 1puf_A, 1fjl_B, 2h1k_B, 1ig7_A, 6a8r_A, 3cmy_A, 3d1n_M, 3lnq_A, 6m3d_C, 2lkx_A, 1zq3_P, 1jgg_B, 2ld5_A, 2r5y_A, 2hos_A, 5zjt_E, 3a01_E, 1b72_A, 5hod_A, 3rkq_B, 1puf_B, 2h8r_B, 5jlw_D, 4cyc_A, 2hdd_A, 7psx_B, 4j19_B, 7q3o_C, 1le8_A, 2d5v_B, 1k61_B, 5flv_I, 4qtr_D, 6fqq_E, 4xrm_B, 1le8_B, 1du0_A, 6es3_K, 4xrs_G, 1mnm_C |
| Binding Motifs: | PBX2_HUMAN.H10MO.C|M01428 krawkTGATTGAwkg MA1113.1 gtGAtTGACAgs MA1113.2 rhcATAAATCAtw MA1113.3 cATAAATCA |
| Binding Sites: | MA1113.1.1 MA1113.1.10 MA1113.1.11 MA1113.1.12 MA1113.1.13 MA1113.1.14 MA1113.1.15 MA1113.1.16 MA1113.1.17 MA1113.1.18 MA1113.1.19 MA1113.1.2 MA1113.1.20 MA1113.1.3 MA1113.1.4 MA1113.1.5 MA1113.1.6 MA1113.1.7 MA1113.1.8 MA1113.1.9 MA1113.2.1 MA1113.2.10 MA1113.2.11 MA1113.2.12 MA1113.2.13 / MA1113.2.5 MA1113.2.14 MA1113.2.15 MA1113.2.16 / MA1113.2.6 MA1113.2.17 / MA1113.2.7 MA1113.2.18 / MA1113.2.8 MA1113.2.19 / MA1113.2.9 MA1113.2.2 MA1113.2.20 MA1113.2.3 MA1113.2.4 MA1113.2.5 MA1113.2.6 MA1113.2.7 MA1113.2.3 / MA1113.2.8 MA1113.2.4 / MA1113.2.9 MA1113.2.10 MA1113.2.11 MA1113.2.12 MA1113.2.13 MA1113.2.14 MA1113.2.15 MA1113.2.16 MA1113.2.17 MA1113.2.18 MA1113.2.19 MA1113.2.20 MA1113.3.1 MA1113.3.10 MA1113.3.11 MA1113.3.12 MA1113.3.13 MA1113.3.14 / MA1113.3.19 / MA1113.3.4 MA1113.3.15 MA1113.3.16 MA1113.3.17 MA1113.3.18 MA1113.3.2 MA1113.3.20 MA1113.3.3 MA1113.3.5 / MA1113.3.8 MA1113.3.6 MA1113.3.7 MA1113.3.9 |
| Publications: | Shen W. F., Rozenfeld S., Kwong A., Kom ves L. G., Lawrence H. J., Largman C. HOXA9 forms triple complexes with PBX2 and MEIS1 in myeloid cells.. Mol. Cell. Biol. 19:3051-3061 (1999). [Pubmed] Brake RL, Kees UR, Watt PM. A complex containing PBX2 contributes to activation of the proto-oncogene HOX11. Biochem Biophys Res Commun 294:23-34 (2002). [Pubmed] |
| Related annotations: | PaperBLAST |
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