Transcription Factor
| Accessions: | UP00610C (UniPROBE 20160601) |
| Names: | KPD, MGC129960, MODY9, paired box protein Pax-4, PAX4_R192H |
| Organisms: | Homo sapiens |
| Libraries: | UniPROBE 20160601 1 1 Hume MA, Barrera LA, Gisselbrecht SS, Bulyk ML. UniPROBE, update 2015: new tools and content for the online database of protein-binding microarray data on protein-DNA interactions. Nucleic Acids Res : (2015). [Pubmed] |
| Description: | paired box protein Pax-4: This gene is a member of the paired box (PAX) family of transcription factors. Members of this gene family typically contain a paired box domain, an octapeptide, and a paired-type homeodomain. These genes play critical roles during fetal development and cancer growth. The paired box 4 gene is involved in pancreatic islet development and mouse studies have demonstrated a role for this gene in differentiation of insulin-producing beta cells. |
| Length: | 218 |
| Pfam Domains: | 1-103 'Paired box' domain 146-201 Homeobox domain |
| Sequence: (in bold interface residues) | 1 RQQIVRLAVSGMRPCDISRILKVSNGCVSKILGRYYRTGVLEPKGIGGSKPRLATPPVVA 60 61 RIAQLKGECPALFAWEIQRQLCAEGLCTQDKTPSVSSINRVLRALQEDQGLPCTRLRSPA 120 121 VLAPAVLTPHSGSETPRGTHPGTGHRNRTIFSPSQAEALEKEFQRGQYPDSVAHGKLATA 180 181 TSLPEDTVRVWFSNRRAKWRRQEKLKWEMQLPGASQGL |
| Interface Residues: | 24, 25, 27, 29, 30, 46, 49, 52, 94, 95, 96, 97, 99, 100, 103, 143, 145, 146, 147, 148, 186, 187, 189, 190, 193, 194, 197, 198, 201 |
| 3D-footprint Homologues: | 1pdn_C, 6pax_A, 1k78_A, 1mnm_C, 3d1n_M, 5zfz_A, 1le8_B, 1k61_B, 1fjl_B, 1puf_A, 1jgg_B, 1zq3_P, 3lnq_A, 2lkx_A, 1nk2_P, 6es3_K, 7q3o_C, 2ld5_A, 4xrs_G, 2hos_A, 4cyc_A, 6m3d_C, 5flv_I, 3l1p_A, 5zjt_E, 1au7_A, 3a01_E, 2h1k_B, 5hod_A, 6a8r_A, 1b72_A, 3cmy_A, 2hdd_A, 7psx_B, 1ig7_A, 5jlw_D, 3rkq_B, 2r5y_A, 1puf_B, 1le8_A, 2xsd_C, 1e3o_C, 7xrc_C, 1du0_A, 1o4x_A, 8g87_X, 4qtr_D, 4j19_B |
| Binding Motifs: | UP00610C_1 aakwsswyTAATTArygsacbw UP00610C_2 aakwgswyTAATTArygsacbw |
| Binding Sites: | AATTAATT AATTAGTG ACCAATTA ACTAATTA ATTAATTA ATTAATTG CAAATTAA CAATTAAG CCAATTAA CCAATTAG CCTAATTA CTAATTAA CTAATTAG CTTAATTA GCTAATTA GTAATTAA GTTAATTA TAATTAAA TAATTAGA TTAATTAA AATTAAGA AATTAAGC |
| Publications: | Barrera LA, Vedenko A, Kurland JV, Rogers JM, Gisselbrecht SS, Rossin EJ, Woodard J, Mariani L, Kock KH, Inukai S, Siggers T, Shokri L, Gordân R, Sahni N, Cotsapas C, Hao T, Yi S, Kellis M, Daly MJ, Vidal M, Hill DE, Bulyk ML. Survey of variation in human transcription factors reveals prevalent DNA binding changes. Science 351:1450-4 (2016). [Pubmed] |
| Related annotations: | PaperBLAST |
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