Transcription Factor
| Accessions: | 5cbx_A (3D-footprint 20231221) |
| Names: | AncGR DNA Binding Domain, GCR_HUMAN, Glucocorticoid receptor, Nuclear receptor subfamily 3 group C member 1 |
| Organisms: | Homo sapiens |
| Libraries: | 3D-footprint 20231221 1 1 Contreras-Moreira B. 3D-footprint: a database for the structural analysis of protein-DNA complexes. Nucleic acids research 38:D91-7 (2010). [Pubmed] |
| Uniprot: | P04150 |
| Length: | 72 |
| Pfam Domains: | 2-69 Zinc finger, C4 type (two domains) |
| Sequence: (in bold interface residues) | 1 KICLVCGDEASGCHYGVLTCGSCKVFFKRAVEGQHNYLCAGRNDCIIDKIRRKNCPACRF 60 61 RKCLQAGMNLEA |
| Interface Residues: | 11, 12, 14, 15, 21, 22, 24, 25, 28, 29, 53 |
| 3D-footprint Homologues: | 6fbq_A, 7wnh_D, 6l6q_B, 3g9m_B, 1a6y_A, 1lo1_A, 4oln_B, 8hbm_B, 5krb_G, 2han_B, 1kb2_B, 2a66_A, 2nll_B, 1lat_A, 7xv6_B, 2ff0_A, 1dsz_A, 4umm_E, 3cbb_A, 8cef_H, 4iqr_B, 2han_A, 1hcq_E, 5cbz_E, 4tnt_B, 5e69_A, 4hn5_B, 5emc_A, 7prw_B, 5cbx_B, 3g6t_A, 1r4i_A |
| Binding Motifs: | 5cbx_AB GnnCAnnnTGTnC |
| Publications: | Hudson WH, Kossmann BR, de Vera IM, Chuo SW, Weikum ER, Eick GN, Thornton JW, Ivanov IN, Kojetin DJ, Ortlund EA. Distal substitutions drive divergent DNA specificity among paralogous transcription factors through subdivision of conformational space. Proc Natl Acad Sci U S A 113:326-31 (2016). [Pubmed] |
| Related annotations: | PaperBLAST |
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