Transcription Factor
| Accessions: | PRRX1_full (HumanTF 1.0) |
| Names: | Homeobox protein PHOX1, Paired mesoderm homeobox protein 1, Paired-related homeobox protein 1, PRRX1, PRRX1_HUMAN, PRX-1 |
| Organisms: | Homo sapiens |
| Libraries: | HumanTF 1.0 1 1 Jolma A, Yan J, Whitington T, Toivonen J, Nitta KR, Rastas P, Morgunova E, Enge M, Taipale M, Wei G, Palin K, Vaquerizas JM, Vincentelli R, Luscombe NM, Hughes TR, Lemaire P, Ukkonen E, Kivioja T, Taipale J. DNA-Binding Specificities of Human Transcription Factors. Cell. 2013 Jan 17;152(1-2):327-39. [Pubmed] |
| Uniprot: | P54821 |
| Notes: | Ensembl ID: ENSG00000116132; Full protein sequence; TF family: homeodomain; Clone source: Megaman |
| Length: | 246 |
| Pfam Domains: | 95-151 Homeobox domain 219-236 OAR domain |
| Sequence: (in bold interface residues) | 1 MTSSYGHVLERQPALGGRLDSPGNLDTLQAKKNFSVSHLLDLEEAGDMVAAQADENVGEA 60 61 GRSLLESPGLTSGSDTPQQDNDQLNSEEKKKRKQRRNRTTFNSSQLQALERVFERTHYPD 120 121 AFVREDLARRVNLTEARVQVWFQNRRAKFRRNERAMLANKNASLLKSYSGDVTAVEQPIV 180 181 PRPAPRPTDYLSWGTASPYSAMATYSATCANNSPAQGINMANSIANLRLKAKEYSLQRNQ 240 241 VPTVN* |
| Interface Residues: | 35, 37, 38, 81, 94, 95, 96, 97, 98, 136, 137, 139, 140, 143, 144, 147, 148, 151 |
| 3D-footprint Homologues: | 7vwz_G, 5zfz_A, 4j19_B, 2h1k_B, 1puf_A, 1fjl_B, 6a8r_A, 3cmy_A, 1ig7_A, 3d1n_M, 1jgg_B, 6m3d_C, 3lnq_A, 2lkx_A, 1nk2_P, 1zq3_P, 2ld5_A, 7q3o_C, 6es3_K, 4cyc_A, 1au7_A, 5flv_I, 3l1p_A, 3a01_E, 2h8r_B, 7psx_B, 1b72_A, 5hod_A, 1puf_B, 1ic8_B, 2hdd_A, 5jlw_D, 3rkq_B, 2r5y_A, 4xrs_G, 2hos_A, 1e3o_C, 2xsd_C, 7xrc_C, 1le8_A, 5zjt_E, 8g87_X, 4qtr_D, 1du0_A, 1o4x_A |
| Binding Motifs: | PRRX1_full_1 cyAATTAr PRRX1_full_2 TAAtytAATTA |
| Publications: | Jolma A, Yan J, Whitington T, Toivonen J, Nitta KR, Rastas P, Morgunova E, Enge M, Taipale M, Wei G, Palin K, Vaquerizas JM, Vincentelli R, Luscombe NM, Hughes TR, Lemaire P, Ukkonen E, Kivioja T, Taipale J. DNA-Binding Specificities of Human Transcription Factors. Cell. 2013 Jan 17;152(1-2):327-39. [Pubmed] |
| Related annotations: | PaperBLAST |
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