Transcription Factor
| Accessions: | NFAC2_MOUSE (HOCOMOCO 10), Q60591 (JASPAR 2024) |
| Names: | NF-ATc2, NF-ATp, NFAC2_MOUSE, NFAT pre-existing subunit, NFATc2, Nuclear factor of activated T-cells, cytoplasmic 2, T-cell transcription factor NFAT1 |
| Organisms: | Mus musculus |
| Libraries: | HOCOMOCO 10 1, JASPAR 2024 2 1 Kulakovskiy IV, Vorontsov IE, Yevshin IS, Soboleva AV, Kasianov AS, Ashoor H, Ba-Alawi W, Bajic VB, Medvedeva YA, Kolpakov FA, Makeev VJ. HOCOMOCO: expansion and enhancement of the collection of transcription factor binding sites models. Nucleic Acids Res : (2016). [Pubmed] 2 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed] |
| Uniprot: | Q60591 |
| Length: | 927 |
| Pfam Domains: | 412-572 Rel homology domain (RHD) 592-677 IPT/TIG domain |
| Sequence: (in bold interface residues) | 1 MDVPEPQPDPDGGDGPGHEPGGSPQDELDFSILFDYDYLNPIEEEPIAHKAISSPSGLAY 60 61 PDDVLDYGLKPCNPLASLSGEPPGRFGEPDSIGFQNFLSPVKPAGASGPSPRIEITPSHE 120 121 LMQAGGALRGRDAGLSPEQPALALAGVAASPRFTLPVPGYEGYREPLCLSPASSGSSASF 180 181 ISDTFSPYTSPCVSPNNAGPDDLCPQFQNIPAHYSPRTSPIMSPRTSLAEDSCLGRHSPV 240 241 PRPASRSSSPGAKRRHSCAEALVAPLPAASPQRSRSPSPQPSPHVALQDDSIPAGYPPTA 300 301 GSAVLMDALNTLATDSPCGIPSKIWKTSPDPTPVSTAPSKAGLARHIYPTVEFLGPCEQE 360 361 ERRNSAPESILLVPPTWPKQLVPAIPICSIPVTASLPPLEWPLSNQSGSYELRIEVQPKP 420 421 HHRAHYETEGSRGAVKAPTGGHPVVQLHGYMENKPLGLQIFIGTADERILKPHAFYQVHR 480 481 ITGKTVTTTSYEKIVGNTKVLEIPLEPKNNMRATIDCAGILKLRNADIELRKGETDIGRK 540 541 NTRVRLVFRVHVPEPSGRIVSLQAASNPIECSQRSAHELPMVERQDMDSCLVYGGQQMIL 600 601 TGQNFTAESKVVFMEKTTDGQQIWEMEATVDKDKSQPNMLFVEIPEYRNKHIRVPVKVNF 660 661 YVINGKRKRSQPQHFTYHPVPAIKTEPSDEYEPSLICSPAHGGLGSQPYYPQHPMLAESP 720 721 SCLVATMAPCQQFRSGLSSPDARYQQQSPAAALYQRSKSLSPGLLGYQQPSLLAAPLGLA 780 781 DAHRSVLVHAGSQGQGQGSTLPHTSSASQQASPVIHYSPTNQQLRGGGHQEFQHIMYCEN 840 841 FGPSSARPGPPPINQGQRLSPGAYPTVIQQQTAPSQRAAKNGPSDQKEALPTGVTVKQEQ 900 901 NLDQTYLDDVNEIIRKEFSGPPSRNQT |
| Interface Residues: | 423, 425, 426, 428, 429, 432, 522, 539, 573, 574, 575, 604, 666, 667 |
| 3D-footprint Homologues: | 1imh_C, 1p7h_L, 1a66_A, 2o61_A, 2ram_A |
| Binding Motifs: | NFAC2_MOUSE.H10MO.B|M01230 wGGAAAAwt MA0152.2 wdgmaATGGAAAmwwt MA0152.3 aATGGAAA |
| Binding Sites: | MA0152.3.1 / MA0152.3.17 MA0152.3.5 MA0152.2.1 MA0152.2.10 MA0152.2.11 / MA0152.2.13 MA0152.2.12 / MA0152.2.14 MA0152.2.13 / MA0152.2.15 MA0152.2.14 / MA0152.2.16 MA0152.2.15 / MA0152.2.18 MA0152.2.16 MA0152.2.17 MA0152.2.18 MA0152.2.19 MA0152.2.2 MA0152.2.20 MA0152.2.3 / MA0152.2.4 MA0152.2.4 / MA0152.2.5 MA0152.2.5 / MA0152.2.6 MA0152.2.6 / MA0152.2.7 MA0152.2.7 MA0152.2.10 / MA0152.2.8 MA0152.2.11 / MA0152.2.9 MA0152.2.12 MA0152.2.17 MA0152.2.19 MA0152.2.20 MA0152.2.3 MA0152.2.8 MA0152.2.9 MA0152.3.10 MA0152.3.11 MA0152.3.12 MA0152.3.13 / MA0152.3.2 MA0152.3.14 / MA0152.3.16 / MA0152.3.3 MA0152.3.15 / MA0152.3.20 MA0152.3.18 MA0152.3.19 / MA0152.3.6 / MA0152.3.8 MA0152.3.4 MA0152.3.7 MA0152.3.9 |
| Publications: | Portales-Casamar E, Kirov S, Lim J, Lithwick S, Swanson M.I, Ticoll A, Snoddy J, Wasserman W.W. PAZAR: a framework for collection and dissemination of cis-regulatory sequence annotation. Genome biology 8:R207 (2007). [Pubmed] |
| Related annotations: | PaperBLAST |
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