Transcription Factor

Accessions: 6fqp_B (3D-footprint 20231221)
Names: 5'-TG-3'-interacting factor 1, Homeobox protein TGIF1, TGIF1_HUMAN
Organisms: Homo sapiens
Libraries: 3D-footprint 20231221 1
1 Contreras-Moreira B. 3D-footprint: a database for the structural analysis of protein-DNA complexes. Nucleic acids research 38:D91-7 (2010). [Pubmed]
Uniprot: Q15583
Length: 66
Pfam Domains: 2-58 Homeobox domain
19-58 Homeobox KN domain
(in bold interface residues)
Interface Residues: 2, 3, 4, 5, 49, 50, 53, 54, 55, 57, 58
3D-footprint Homologues: 6fqp_B, 1zq3_P, 1puf_B, 1le8_A, 4j19_B, 1du0_A, 1le8_B, 6fqq_E, 2d5v_B, 1fjl_B, 4xrm_B, 1mnm_C, 7psx_B, 2hdd_A, 1k61_B, 5zjt_E, 2hos_A
Binding Motifs: 6fqp_AB TGACAgCtGTCA
6fqp_B ctGTCA
Binding Sites: 6fqp_L / 6fqp_M
Publications: Guca E, Suñol D, Ruiz L, Konkol A, Cordero J, Torner C, Aragon E, Martin-Malpartida P, Riera A, Macias MJ. TGIF1 homeodomain interacts with Smad MH1 domain and represses TGF-β signaling. Nucleic Acids Res 46:9220-9235 (2018). [Pubmed]
Related annotations: PaperBLAST

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