Transcription Factor
| Accessions: | UP00589A (UniPROBE 20160601) |
| Names: | ARA, FKHL7, forkhead box protein C1, Forkhead-related protein FKHL7, Forkhead-related transcription factor 3, FOXC1_REF, FREAC-3, FREAC3, IGDA, IHG1, IRID1, RIEG3 |
| Organisms: | Homo sapiens |
| Libraries: | UniPROBE 20160601 1 1 Hume MA, Barrera LA, Gisselbrecht SS, Bulyk ML. UniPROBE, update 2015: new tools and content for the online database of protein-binding microarray data on protein-DNA interactions. Nucleic Acids Res : (2015). [Pubmed] |
| Description: | forkhead box protein C1: Binding of FREAC-3 and FREAC-4 to their cognate sites results in bending of the DNA at an angle of 80-90 degrees. Regulates FOXO1 through binding to a conserved element, 5'-GTAAACAAA-3' in its promoter region, implicating FOXC1 as an important regulator of cell viability and resistance to oxidative stress in the eye. |
| Length: | 125 |
| Pfam Domains: | 15-110 Fork head domain |
| Sequence: (in bold interface residues) | 1 YGPYTPQPQPKDMVKPPYSYIALITMAIQNAPDKKITLNGIYQFIMDRFPFYRDNKQGWQ 60 61 NSIRHNLSLNECFVKVPRDDKKPGKGSYWTLDPDSYNMFENGSFLRRRRRFKKKDAVKDK 120 121 EEKDR |
| Interface Residues: | 55, 58, 60, 61, 62, 64, 65, 66, 68, 69, 78, 85, 110 |
| 3D-footprint Homologues: | 3l2c_A, 7vox_H, 2hdc_A, 7yzg_A, 7tdw_A, 3g73_A, 7yz7_A, 6el8_A, 7tdx_A, 7yzb_A, 6nce_A, 2uzk_A, 7vou_C, 2a07_J, 7yze_A, 7cby_C, 3co6_C, 6ako_C, 2c6y_A, 3qrf_G |
| Binding Motifs: | UP00589A_1 wkagkywAwrTAAAyAwagrgrk |
| Binding Sites: | GTAAACAA AAAACAAA AAATAACA AATAAACA AGTAAACA ATAAACAA ATAAACAC ATAAACAT ATGTTTAC ATTGTTTA CATAAACA CGTAAACA GATAAACA GTAAATAA TAAACAAA TAAACATA TATAAACA TATTTACA TGTAAACA AATAACAA |
| Publications: | Barrera LA, Vedenko A, Kurland JV, Rogers JM, Gisselbrecht SS, Rossin EJ, Woodard J, Mariani L, Kock KH, Inukai S, Siggers T, Shokri L, Gordân R, Sahni N, Cotsapas C, Hao T, Yi S, Kellis M, Daly MJ, Vidal M, Hill DE, Bulyk ML. Survey of variation in human transcription factors reveals prevalent DNA binding changes. Science 351:1450-4 (2016). [Pubmed] |
| Related annotations: | PaperBLAST |
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