Transcription Factor

Accessions: UP00589A (UniPROBE 20160601)
Names: ARA, FKHL7, forkhead box protein C1, Forkhead-related protein FKHL7, Forkhead-related transcription factor 3, FOXC1_REF, FREAC-3, FREAC3, IGDA, IHG1, IRID1, RIEG3
Organisms: Homo sapiens
Libraries: UniPROBE 20160601 1
1 Hume MA, Barrera LA, Gisselbrecht SS, Bulyk ML. UniPROBE, update 2015: new tools and content for the online database of protein-binding microarray data on protein-DNA interactions. Nucleic Acids Res : (2015). [Pubmed]
Description: forkhead box protein C1: Binding of FREAC-3 and FREAC-4 to their cognate sites results in bending of the DNA at an angle of 80-90 degrees. Regulates FOXO1 through binding to a conserved element, 5'-GTAAACAAA-3' in its promoter region, implicating FOXC1 as an important regulator of cell viability and resistance to oxidative stress in the eye.
Length: 125
Pfam Domains: 15-110 Fork head domain
Sequence:
(in bold interface residues)
1 YGPYTPQPQPKDMVKPPYSYIALITMAIQNAPDKKITLNGIYQFIMDRFPFYRDNKQGWQ 60
61 NSIRHNLSLNECFVKVPRDDKKPGKGSYWTLDPDSYNMFENGSFLRRRRRFKKKDAVKDK 120
121 EEKDR
Interface Residues: 55, 58, 60, 61, 62, 64, 65, 66, 68, 69, 78, 85, 110
3D-footprint Homologues: 3l2c_A, 7vox_H, 2hdc_A, 7cby_C, 3co6_C, 6ako_C, 2c6y_A, 7yzg_A, 7tdw_A, 3g73_A, 7yz7_A, 6el8_A, 7tdx_A, 7yzb_A, 6nce_A, 2uzk_A, 7vou_C, 2a07_J, 7yze_A, 3qrf_G
Binding Motifs: UP00589A_1 wkagkywAwrTAAAyAwagrgrk
Binding Sites: GTAAACAA
AAAACAAA
AAATAACA
AATAAACA
AGTAAACA
ATAAACAA
ATAAACAC
ATAAACAT
ATGTTTAC
ATTGTTTA
CATAAACA
CGTAAACA
GATAAACA
GTAAATAA
TAAACAAA
TAAACATA
TATAAACA
TATTTACA
TGTAAACA
AATAACAA
Publications: Barrera LA, Vedenko A, Kurland JV, Rogers JM, Gisselbrecht SS, Rossin EJ, Woodard J, Mariani L, Kock KH, Inukai S, Siggers T, Shokri L, Gordân R, Sahni N, Cotsapas C, Hao T, Yi S, Kellis M, Daly MJ, Vidal M, Hill DE, Bulyk ML. Survey of variation in human transcription factors reveals prevalent DNA binding changes. Science 351:1450-4 (2016). [Pubmed]
Related annotations: PaperBLAST

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