Transcription Factor
| Accessions: | Q9UN79 (JASPAR 2024) |
| Names: | Islet cell antigen 12, SOX13_HUMAN, SRY (Sex determining region Y, Transcription factor SOX-13, Type 1 diabetes autoantigen ICA12 |
| Organisms: | Homo sapiens |
| Libraries: | JASPAR 2024 1 1 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed] |
| Uniprot: | Q9UN79 |
| Length: | 622 |
| Pfam Domains: | 424-492 HMG (high mobility group) box 425-485 Domain of unknown function (DUF1898) |
| Sequence: (in bold interface residues) | 1 MSMRSPISAQLALDGVGTMVNCTIKSEEKKEPCHEAPQGSATAAEPQPGDPARASQDSAD 60 61 PQAPAQGNFRGSWDCSSPEGNGSPEPKRPGVSEAASGSQEKLDFNRNLKEVVPAIEKLLS 120 121 SDWKERFLGRNSMEAKDVKGTQESLAEKELQLLVMIHQLSTLRDQLLTAHSEQKNMAAML 180 181 FEKQQQQMELARQQQEQIAKQQQQLIQQQHKINLLQQQIQQVNMPYVMIPAFPPSHQPLP 240 241 VTPDSQLALPIQPIPCKPVEYPLQLLHSPPAPVVKRPGAMATHHPLQEPSQPLNLTAKPK 300 301 APELPNTSSSPSLKMSSCVPRPPSHGGPTRDLQSSPPSLPLGFLGEGDAVTKAIQDARQL 360 361 LHSHSGALDGSPNTPFRKDLISLDSSPAKERLEDGCVHPLEEAMLSCDMDGSRHFPESRN 420 421 SSHIKRPMNAFMVWAKDERRKILQAFPDMHNSSISKILGSRWKSMTNQEKQPYYEEQARL 480 481 SRQHLEKYPDYKYKPRPKRTCIVEGKRLRVGEYKALMRTRRQDARQSYVIPPQAGQVQMS 540 541 SSDVLYPRAAGMPLAQPLVEHYVPRSLDPNMPVIVNTCSLREEGEGTDDRHSVADGEMYR 600 601 YSEDEDSEGEEKSDGELVVLTD |
| Interface Residues: | 426, 429, 431, 432, 435, 439, 450, 451, 452, 455, 493 |
| 3D-footprint Homologues: | 4s2q_D, 1j5n_A, 2lef_A, 4y60_C, 1o4x_B, 3f27_D, 6jrp_D, 1qrv_A, 3u2b_C, 7m5w_A, 2gzk_A, 1hry_A |
| Binding Motifs: | MA1120.1 raACAATGgmw MA1120.2 ACAATGg |
| Binding Sites: | MA1120.2.3 MA1120.2.13 MA1120.1.1 MA1120.1.10 MA1120.1.11 MA1120.1.12 MA1120.1.13 MA1120.1.14 MA1120.1.15 MA1120.1.16 MA1120.1.17 MA1120.1.18 MA1120.1.19 MA1120.1.2 MA1120.1.20 MA1120.1.3 MA1120.1.4 MA1120.1.5 MA1120.1.6 MA1120.1.7 MA1120.1.8 MA1120.1.9 MA1120.2.12 / MA1120.2.16 / MA1120.2.17 / MA1120.2.4 / MA1120.2.8 MA1120.2.19 / MA1120.2.20 / MA1120.2.6 MA1120.2.11 / MA1120.2.2 MA1120.2.5 MA1120.2.18 / MA1120.2.7 MA1120.2.9 MA1120.2.1 MA1120.2.10 / MA1120.2.14 MA1120.2.15 |
| Publications: | Hou L, Srivastava Y, Jauch R. Molecular basis for the genome engagement by Sox proteins. Semin Cell Dev Biol : (2017). [Pubmed] |
| Related annotations: | PaperBLAST |
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These data are available AS IS and at your own risk. The EEAD/CSIC do not give any representation or warranty nor assume any liability or responsibility for the data nor the results posted (whether as to their accuracy, completeness, quality or otherwise). Access to these data is available free of charge for ordinary use in the course of research. Downloaded data have CC-BY-NC-SA license. FootprintDB is also available at RSAT::Plants, part of the INB/ELIXIR-ES resources portfolio.