Transcription Factor
| Accessions: | 5cbz_E (3D-footprint 20231221) |
| Names: | AncMR DNA Binding Domain, GCR_HUMAN, Glucocorticoid receptor, GR, Nuclear receptor subfamily 3 group C member 1 |
| Organisms: | Homo sapiens |
| Libraries: | 3D-footprint 20231221 1 1 Contreras-Moreira B. 3D-footprint: a database for the structural analysis of protein-DNA complexes. Nucleic acids research 38:D91-7 (2010). [Pubmed] |
| Uniprot: | P04150 |
| Length: | 76 |
| Pfam Domains: | 5-72 Zinc finger, C4 type (two domains) |
| Sequence: (in bold interface residues) | 1 PPSKVCLVCGDEASGCHYGVLTCGSCKVFFKRAVEGQHNYLCAGRNDCIIDKIRRKNCPA 60 61 CRLRKCLQAGMNLGAR |
| Interface Residues: | 14, 15, 17, 18, 24, 25, 27, 28, 31, 32, 56 |
| 3D-footprint Homologues: | 6fbq_A, 7wnh_D, 6l6q_B, 3g9m_B, 1a6y_A, 1lo1_A, 4oln_B, 4iqr_B, 2han_A, 1hcq_E, 8hbm_B, 5krb_G, 2han_B, 1kb2_B, 2a66_A, 2nll_B, 1lat_A, 7xv6_B, 2ff0_A, 1dsz_A, 4umm_E, 3cbb_A, 8cef_H, 5emc_A, 7prw_B, 5cbx_B, 3g6t_A, 1r4i_A, 5cbz_E, 4tnt_B, 5e69_A, 4hn5_B |
| Binding Motifs: | 5cbz_E TGtnc 5cbz_EF GnrCAnnnTGwnC |
| Binding Sites: | 5cbz_G 5cbz_H |
| Publications: | Hudson WH, Kossmann BR, de Vera IM, Chuo SW, Weikum ER, Eick GN, Thornton JW, Ivanov IN, Kojetin DJ, Ortlund EA. Distal substitutions drive divergent DNA specificity among paralogous transcription factors through subdivision of conformational space. Proc Natl Acad Sci U S A 113:326-31 (2016). [Pubmed] |
| Related annotations: | PaperBLAST |
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