Transcription Factor

						

			
Accessions: 1au7_A (3D-footprint 20231221)

			
Names: GHF-1, Growth hormone factor 1, PIT1_RAT, Pituitary-specific positive transcription factor 1, PROTEIN PIT-1
Organisms: Rattus norvegicus
Libraries: 3D-footprint 20231221 1
1 Contreras-Moreira B. 3D-footprint: a database for the structural analysis of protein-DNA complexes. Nucleic acids research 38:D91-7 (2010). [Pubmed]
Uniprot: P10037
Length: 130
Pfam Domains:      3-71 Pou domain - N-terminal to homeobox domain
   73-128 Homeobox domain
Sequence: 
(in bold interface residues)		   1 GMRALEQFANEFKVRRIKLGYTQTNVGEALAAVHGSEFSQTTICRFENLQLSFKNACKLK   60
  61 AILSKWLEEAEQKRRTTISIAAKDALERHFGEHSKPSSQEIMRMAEELNLEKEVVRVWFC  120
 121 NRRQREKRVK
Interface Residues: 23, 39, 40, 41, 42, 44, 45, 47, 48, 51, 55, 72, 73, 75, 113, 114, 116, 117, 120, 121, 124, 125, 128
3D-footprint Homologues: 3d1n_M, 7u0g_M, 3l1p_A, 8g87_X, 1e3o_C, 1au7_A, 2xsd_C, 1o4x_A, 7xrc_C, 2d5v_B, 6a8r_A, 3cmy_A, 1fjl_B, 5zfz_A, 2lkx_A, 1nk2_P, 6m3d_C, 5hod_A, 3lnq_A, 2hdd_A, 3rkq_B, 2r5y_A, 4xrs_G, 2hos_A, 1b72_A, 1ig7_A, 5flv_I, 5zjt_E, 2h1k_B, 1jgg_B, 7psx_B, 5jlw_D, 2ld5_A, 1le8_A, 7q3o_C, 1puf_A, 4xrm_B, 1zq3_P, 6es3_K, 4cyc_A, 1du0_A, 4qtr_D, 3a01_E
Binding Motifs: 1au7_A TGTATATaCAT
1au7_AB tcATGTATATACAT
Binding Sites: 1au7_C
1au7_D
			
Publications: Jacobson E.M, Li P, Leon-del-Rio A, Rosenfeld M.G, Aggarwal A.K. Structure of Pit-1 POU domain bound to DNA as a dimer: unexpected arrangement and flexibility. Genes & development 11:198-212 (1997). [Pubmed]
Related annotations: PaperBLAST

	
			


			

				

				
				
				
				

			

			

		

	
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