Transcription Factor
| Accessions: | UP00073A (UniPROBE 20160601) |
| Names: | forkhead box A2, Forkhead box protein A2, Foxa2, Hepatocyte nuclear factor 3-beta, Hnf-3b, HNF3-beta, Hnf3b, HNF3beta, Tcf-3b, Tcf3b |
| Organisms: | Mus musculus |
| Libraries: | UniPROBE 20160601 1 1 Hume MA, Barrera LA, Gisselbrecht SS, Bulyk ML. UniPROBE, update 2015: new tools and content for the online database of protein-binding microarray data on protein-DNA interactions. Nucleic Acids Res : (2015). [Pubmed] |
| Uniprot: | P35583 |
| Description: | forkhead box A2: Mus musculus forkhead box A2 (Foxa2) |
| Length: | 128 |
| Pfam Domains: | 2-17 Forkhead N-terminal region 18-113 Fork head domain |
| Sequence: (in bold interface residues) | 1 LSRARDPKTYRRSYTHAKPPYSYISLITMAIQQSPNKMLTLSEIYQWIMDLFPFYRQNQQ 60 61 RWQNSIRHSLSFNDCFLKVPRSPDKPGKGSFWTLHPDSGNMFENGCYLRRQKRFKCEKQL 120 121 ALKEAAGA |
| Interface Residues: | 8, 10, 12, 13, 15, 58, 61, 63, 64, 65, 67, 68, 69, 71, 72, 81, 88, 113 |
| 3D-footprint Homologues: | 7yz7_A, 7yzb_A, 3l2c_A, 7vox_H, 2hdc_A, 7cby_C, 3co6_C, 6ako_C, 2c6y_A, 7yzg_A, 7tdw_A, 3g73_A, 6el8_A, 7tdx_A, 6nce_A, 2uzk_A, 7vou_C, 2a07_J, 7yze_A, 3qrf_G |
| Binding Motifs: | UP00073A_1 wawawGTAAAyAAwvab UP00073A_2 rrwaaTAACAaasgs |
| Binding Sites: | AATAAACA AGTAAACA AGTAAATA ATAAACAA ATATTTAC ATGTTTAC CTATTTAC CTGTTTAC GGTAAACA GGTAAATA GTAAACAC GTAAATAA GTACACAA GTCAACAA TAAACAAA TAAATAAA TATTGACA TATTTACA TGTAAACA TGTCAACA |
| Publications: | Badis G, Berger M.F, Philippakis A.A, Talukder S, Gehrke A.R, Jaeger S.A, Chan E.T, Metzler G, Vedenko A, Chen X, Kuznetsov H, Wang C.F, Coburn D, Newburger D.E, Morris Q, Hughes T.R, Bulyk M.L. Diversity and complexity in DNA recognition by transcription factors. Science (New York, N.Y.) 324:1720-3 (2009). [Pubmed] |
| Related annotations: | PaperBLAST |
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