Transcription Factor

						

			
Accessions: 1bf5_A (3D-footprint 20231221)

			
Names: SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 1-ALPHA/BETA, STAT1_HUMAN, Transcription factor ISGF-3 components p91/p84
Organisms: Homo sapiens
Libraries: 3D-footprint 20231221 1
1 Contreras-Moreira B. 3D-footprint: a database for the structural analysis of protein-DNA complexes. Nucleic acids research 38:D91-7 (2010). [Pubmed]
Uniprot: P42224
Length: 544
Pfam Domains:     2-166 STAT protein, all-alpha domain
  168-418 STAT protein, DNA binding domain
  429-489 SH2 domain
Sequence: 
(in bold interface residues)		   1 LDKQKELDSKVRNVKDKVMCIEHEIKSLEDLQDEYDFKCKTLQNREHLLLKKMYLMLDNK   60
  61 RKEVVHKIIELLNVTELTQNALINDELVEWKRRQQSACIGGPPNACLDQLQNWFTIVAES  120
 121 LQQVRQQLKKLEELEQKYTYEHDPITKNKQVLWDRTFSLFQQLIQSSFVVERQPCMPTHP  180
 181 QRPLVLKTGVQFTVKLRLLVKLQELNYNLKVKVLFDKDVNERNTVKGFRKFNILGTHTKV  240
 241 MNMEESTNGSLAAEFRHLQLKEQKNAGTRTNEGPLIVTEELHSLSFETQLCQPGLVIDLE  300
 301 TTSLPVVVISNVSQLPSGWASILWYNMLVAEPRNLSFFLTPPCARWAQLSEVLSWQFSSV  360
 361 TKRGLNVDQLNMLGEKLLGPNASPDGLIPWTRFCKENINDKNFPFWLWIESILELIKKHL  420
 421 LPLWNDGCIMGFISKERERALLKDQQPGTFLLRFSESSREGAITFTWVERSQNGGEPDFH  480
 481 AVEPYTKKELSAVTFPDIIRNYKVMAAENIPENPLKYLYPNIDKDHAFGKYYSRGIKTEL  540
 541 ISVS
Interface Residues: 187, 272, 310, 311, 312, 313, 314, 439
3D-footprint Homologues: 1bf5_A, 4y5w_B, 1bg1_A, 8gh6_A
Binding Motifs: 1bf5_A GTAanngC
Binding Sites: 1bf5_B
1bf5_C
			
Publications: Chen X, Vinkemeier U, Zhao Y, Jeruzalmi D, Darnell J.E, Kuriyan J. Crystal structure of a tyrosine phosphorylated STAT-1 dimer bound to DNA. Cell 93:827-39 (1998). [Pubmed]
Related annotations: PaperBLAST

	
			


			

				

				
				
				
				

			

			

		

	
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