Transcription Factor
| Accessions: | Q8NB42 (JASPAR 2024) |
| Names: | ZN527_HUMAN |
| Organisms: | Homo sapiens |
| Libraries: | JASPAR 2024 1 1 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed] |
| Uniprot: | Q8NB42 |
| Length: | 609 |
| Pfam Domains: | 14-54 KRAB box 294-313 Zinc-finger double domain 302-324 Zinc finger, C2H2 type 302-324 C2H2-type zinc finger 317-340 Zinc-finger double domain 329-340 C2H2-type zinc finger 330-352 Zinc finger, C2H2 type 330-352 C2H2-type zinc finger 344-369 Zinc-finger double domain 358-380 C2H2-type zinc finger 358-378 C2H2-type zinc finger 358-380 Zinc finger, C2H2 type 373-396 Zinc-finger double domain 385-404 C2H2-type zinc finger 386-408 C2H2-type zinc finger 386-408 Zinc finger, C2H2 type 400-425 Zinc-finger double domain 413-434 C2H2-type zinc finger 414-436 C2H2-type zinc finger 414-436 Zinc finger, C2H2 type 428-453 Zinc-finger double domain 442-464 C2H2-type zinc finger 442-462 C2H2-type zinc finger 442-464 Zinc finger, C2H2 type 456-481 Zinc-finger double domain 470-492 Zinc finger, C2H2 type 485-508 Zinc-finger double domain 498-520 Zinc finger, C2H2 type 498-520 C2H2-type zinc finger 498-520 C2H2-type zinc finger 516-537 Zinc-finger double domain 525-546 C2H2-type zinc finger 526-548 Zinc finger, C2H2 type 526-548 C2H2-type zinc finger 541-564 Zinc-finger double domain 553-574 C2H2-type zinc finger 554-576 C2H2-type zinc finger 568-592 Zinc-finger double domain 581-602 C2H2-type zinc finger 582-604 C2H2-type zinc finger |
| Sequence: (in bold interface residues) | 1 MAVGLCKAMSQGLVTFRDVALDFSQEEWEWLKPSQKDLYRDVMLENYRNLVWLGLSISKP 60 61 NMISLLEQGKEPWMVERKMSQGHCADWESWCEIEELSPKWFIDEDEISQEMVMERLASHG 120 121 LECSSFREAWKYKGEFELHQGNAERHFMQVTAVKEISTGKRDNEFSNSGRSIPLKSVFLT 180 181 QQKVPTIQQVHKFDIYDKLFPQNSVIIEYKRLHAEKESLIGNECEEFNQSTYLSKDIGIP 240 241 PGEKPYESHDFSKLLSFHSLFTQHQTTHFGKLPHGYDECGDAFSCYSFFTQPQRIHSGEK 300 301 PYACNDCGKAFSHDFFLSEHQRTHIGEKPYECKECNKAFRQSAHLAQHQRIHTGEKPFAC 360 361 NECGKAFSRYAFLVEHQRIHTGEKPYECKECNKAFRQSAHLNQHQRIHTGEKPYECNQCG 420 421 KAFSRRIALTLHQRIHTGEKPFKCSECGKTFGYRSHLNQHQRIHTGEKPYECIKCGKFFR 480 481 TDSQLNRHHRIHTGERPFECSKCGKAFSDALVLIHHKRSHAGEKPYECNKCGKAFSCGSY 540 541 LNQHQRIHTGEKPYECSECGKAFHQILSLRLHQRIHAGEKPYKCNECGNNFSCVSALRRH 600 601 QRIHNRETL |
| Interface Residues: | 57, 60, 61, 64, 79, 312, 313, 315, 316, 319, 341, 342, 343, 344, 346, 347, 349, 350, 351, 353, 358, 368, 369, 370, 371, 372, 375, 378, 396, 397, 398, 399, 400, 402, 403, 424, 425, 426, 427, 428, 429, 431, 452, 453, 454, 455, 456, 458, 459, 460, 480, 481, 482, 483, 484, 485, 486, 487, 488, 493, 507, 508, 509, 510, 511, 512, 515, 519, 536, 537, 538, 539, 540, 543, 565, 567, 568, 570, 571, 593, 594, 595, 596, 598, 599 |
| 3D-footprint Homologues: | 4nhj_A, 1tf3_A, 7w1m_H, 6u9q_A, 5ei9_F, 5kl3_A, 5k5i_A, 1tf6_A, 2i13_A, 5yel_A, 1ubd_C, 6blw_A, 5kkq_D, 6wmi_A, 8ssq_A, 5und_A, 1llm_D, 8ssu_A, 2jpa_A, 2kmk_A, 1f2i_J, 2gli_A, 1g2f_F, 4x9j_A, 6e94_A, 7n5w_A, 1mey_C, 2drp_D, 5v3j_F, 8h9h_G, 7eyi_G, 8cuc_F, 7y3l_A, 7txc_E, 5k5l_F, 8gn3_A, 4m9v_C, 7ysf_A, 2wbs_A, 7y3m_I, 2lt7_A, 6ml4_A, 3uk3_C, 6jnm_A, 6a57_A, 5yj3_D |
| Binding Motifs: | UN0625.1 gsCAGCAACAGAarys UN0625.2 gsCAGCAACAGAa |
| Binding Sites: | UN0625.1.1 UN0625.1.10 UN0625.1.11 UN0625.1.12 UN0625.1.13 UN0625.1.14 UN0625.1.15 UN0625.1.16 UN0625.1.17 / UN0625.1.18 UN0625.1.18 / UN0625.1.19 UN0625.1.19 / UN0625.1.20 UN0625.1.2 UN0625.1.20 UN0625.1.3 UN0625.1.4 UN0625.1.5 UN0625.1.6 UN0625.1.7 UN0625.1.8 UN0625.1.9 UN0625.1.17 UN0625.2.1 UN0625.2.10 UN0625.2.11 UN0625.2.12 UN0625.2.13 UN0625.2.14 UN0625.2.15 UN0625.2.16 UN0625.2.17 UN0625.2.18 UN0625.2.19 UN0625.2.2 UN0625.2.20 UN0625.2.3 UN0625.2.4 UN0625.2.5 UN0625.2.6 UN0625.2.7 UN0625.2.8 UN0625.2.9 |
| Related annotations: | PaperBLAST |
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These data are available AS IS and at your own risk. The EEAD/CSIC do not give any representation or warranty nor assume any liability or responsibility for the data nor the results posted (whether as to their accuracy, completeness, quality or otherwise). Access to these data is available free of charge for ordinary use in the course of research. Downloaded data have CC-BY-NC-SA license. FootprintDB is also available at RSAT::Plants, part of the INB/ELIXIR-ES resources portfolio.