Transcription Factor

Accessions: UP00067A (UniPROBE 20160601)
Names: 3000002B05, AI451430, Lef-1, Lef1, lymphoid enhancer binding factor 1, lymphoid enhancer factor 1, Lymphoid enhancer-binding factor 1
Organisms: Mus musculus
Libraries: UniPROBE 20160601 1
1 Hume MA, Barrera LA, Gisselbrecht SS, Bulyk ML. UniPROBE, update 2015: new tools and content for the online database of protein-binding microarray data on protein-DNA interactions. Nucleic Acids Res : (2015). [Pubmed]
Uniprot: P27782
Description: lymphoid enhancer binding factor 1
Length: 101
Pfam Domains: 12-75 Domain of unknown function (DUF1898)
17-85 HMG (high mobility group) box
Sequence:
(in bold interface residues)
1 KPQHEQRKEQEPKRPHIKKPLNAFMLYMKEMRANVVAECTLKESAAINQILGRRWHALSR 60
61 EEQAKYYELARKERQLHMQLYPGWSARDNYGKKKKRKREKL
Interface Residues: 19, 22, 24, 25, 28, 32, 43, 44, 45, 48, 86, 88, 90, 93, 95, 96, 97, 100
3D-footprint Homologues: 2lef_A, 4y60_C, 1o4x_B, 3f27_D, 6jrp_D, 1qrv_A, 3u2b_C, 7m5w_A, 2gzk_A, 4s2q_D, 1j5n_A, 1hry_A
Binding Motifs: UP00067A_1 rrwycCTTTGATstwwm
UP00067A_2 swrsATCAATCrctww
Binding Sites: AATCAAAG
ACATCAAA
ACTTCAAA
ACTTTGAT
AGATCAAA
AGATCAAT
ATCAAAAG
ATCAAAGA
ATCAAAGC
ATCAAAGG
CATCAAAG
CCTTTGAA
CTTCAAAG
CTTTGAAC
CTTTGATA
GATCAAAA
GCCTTTGA
GGATCAAA
TGATCAAA
CTTTCATC
Publications: Badis G, Berger M.F, Philippakis A.A, Talukder S, Gehrke A.R, Jaeger S.A, Chan E.T, Metzler G, Vedenko A, Chen X, Kuznetsov H, Wang C.F, Coburn D, Newburger D.E, Morris Q, Hughes T.R, Bulyk M.L. Diversity and complexity in DNA recognition by transcription factors. Science (New York, N.Y.) 324:1720-3 (2009). [Pubmed]
Related annotations: PaperBLAST

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These data are available AS IS and at your own risk. The EEAD/CSIC do not give any representation or warranty nor assume any liability or responsibility for the data nor the results posted (whether as to their accuracy, completeness, quality or otherwise). Access to these data is available free of charge for ordinary use in the course of research. Downloaded data have CC-BY-NC-SA license. FootprintDB is also available at RSAT::Plants, part of the INB/ELIXIR-ES resources portfolio.