Transcription Factor
| Accessions: | Q8NFJ8 (JASPAR 2024) |
| Names: | BHE22_HUMAN, bHLHb5, bHLHe22, Class B basic helix-loop-helix protein 5, Class E basic helix-loop-helix protein 22, Trinucleotide repeat-containing gene 20 protein |
| Organisms: | Homo sapiens |
| Libraries: | JASPAR 2024 1 1 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed] |
| Uniprot: | Q8NFJ8 |
| Length: | 381 |
| Pfam Domains: | 244-294 Helix-loop-helix DNA-binding domain |
| Sequence: (in bold interface residues) | 1 MERGMHLGAAAAGEDDLFLHKSLSASTSKRLEAAFRSTPPGMDLSLAPPPRERPASSSSS 60 61 PLGCFEPADPEGAGLLLPPPGGGGGGSAGSGGGGGGGVGVPGLLVGSAGVGGDPSLSSLP 120 121 AGAALCLKYGESASRGSVAESSGGEQSPDDDSDGRCELVLRAGVADPRASPGAGGGGAKA 180 181 AEGCSNAHLHGGASVPPGGLGGGGGGGSSSGSSGGGGGSGSGSGGSSSSSSSSSKKSKEQ 240 241 KALRLNINARERRRMHDLNDALDELRAVIPYAHSPSVRKLSKIATLLLAKNYILMQAQAL 300 301 EEMRRLVAYLNQGQAISAASLPSSAAAAAAAAALHPALGAYEQAAGYPFSAGLPPAASCP 360 361 EKCALFNSVSSSLCKQCTEKP |
| Interface Residues: | 244, 246, 247, 248, 250, 251, 252, 254, 255, 280 |
| 3D-footprint Homologues: | 2ypa_A, 1an4_A, 6od3_F, 7d8t_A, 5gnj_I, 6g1l_A, 2ql2_A, 2ql2_D, 2ypa_B, 7z5k_B, 4h10_A, 8osl_P |
| Binding Motifs: | MA0818.1 AmCATATGyy MA1635.1 csCAGCTGsg MA0818.2 AmCATATGky MA1635.2 CAGCTG |
| Binding Sites: | MA1635.2.1 / MA1635.2.10 / MA1635.2.11 / MA1635.2.12 / MA1635.2.13 / MA1635.2.14 / MA1635.2.15 / MA1635.2.16 / MA1635.2.17 / MA1635.2.18 / MA1635.2.19 / MA1635.2.2 / MA1635.2.20 / MA1635.2.3 / MA1635.2.4 / MA1635.2.5 / MA1635.2.6 / MA1635.2.7 / MA1635.2.8 / MA1635.2.9 MA1635.1.1 MA1635.1.10 MA1635.1.11 MA1635.1.12 MA1635.1.13 / MA1635.1.14 MA1635.1.15 MA1635.1.16 MA1635.1.17 MA1635.1.18 MA1635.1.19 MA1635.1.2 MA1635.1.20 MA1635.1.3 MA1635.1.4 MA1635.1.5 / MA1635.1.6 MA1635.1.7 MA1635.1.8 MA1635.1.9 |
| Publications: | Atchley WR, Fitch WM. A natural classification of the basic helix-loop-helix class of transcription factors. Proc Natl Acad Sci U S A 94:5172-6 (1997). [Pubmed] Ross SE, McCord AE, Jung C, Atan D, Mok SI, Hemberg M, Kim TK, Salogiannis J, Hu L, Cohen S, Lin Y, Harrar D, McInnes RR, Greenberg ME. Bhlhb5 and Prdm8 form a repressor complex involved in neuronal circuit assembly. Neuron 73:292-303 (2012). [Pubmed] |
| Related annotations: | PaperBLAST |
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