Transcription Factor
| Accessions: | 1qn3_B (3D-footprint 20231221), 1qn4_B (3D-footprint 20231221), 1qn6_B (3D-footprint 20231221), 1qn8_B (3D-footprint 20231221), 1qnb_B (3D-footprint 20231221), 1qnc_B (3D-footprint 20231221), 1vol_B (3D-footprint 20231221), 6njq_A (3D-footprint 20231221), 6ueo_G (3D-footprint 20231221), 6ueq_B (3D-footprint 20231221), 6uer_A (3D-footprint 20231221) |
| Names: | AtTBP1, TATA sequence-binding protein 1, TATA-binding factor 1, TATA-box factor 1, TATA-box-binding protein 1, TBP-1, TBP1_ARATH, Transcription initiation factor TFIID TBP-1 subunit, TRANSCRIPTION INITIATION FACTOR TFIID-1, TATA BINDING PROTEIN (TBP) |
| Organisms: | Arabidopsis thaliana |
| Libraries: | 3D-footprint 20231221 1 1 Contreras-Moreira B. 3D-footprint: a database for the structural analysis of protein-DNA complexes. Nucleic acids research 38:D91-7 (2010). [Pubmed] |
| Uniprot: | P28147 |
| Length: | 187 |
| Pfam Domains: | 12-94 Transcription factor TFIID (or TATA-binding protein, TBP) 99-185 Transcription factor TFIID (or TATA-binding protein, TBP) |
| Sequence: (in bold interface residues) | 1 VDLSKHPSGIVPTLQNIVSTVNLDCKLDLKAIALQARNAEYNPKRFAAVIMRIREPKTTA 60 61 LIFASGKMVCTGAKSEDFSKMAARKYARIVQKLGFPAKFKDFKIQNIVGSCDVKFPIRLE 120 121 GLAYSHAAFSSYEPELFPGLIYRMKVPKIVLLIFVSGKIVITGAKMRDETYKAFENIYPV 180 181 LSEFRKI |
| Interface Residues: | 16, 18, 46, 47, 61, 63, 69, 71, 105, 106, 108, 137, 138, 152, 154, 160, 162 |
| 3D-footprint Homologues: | 6cnb_R, 1cdw_A, 5iy6_P, 7z7n_D, 1qna_B, 5n9g_G, 1ytb_A, 5oqj_O, 1ais_A, 4wzs_D |
| Binding Motifs: | 1vol_AB / 1vol_B cTtTTATA 1qn3_B TATAAaCg 1qn4_B aTtTTATA 1qn6_B TATAAtAg 1qn8_B CTTTAATA 1qnb_B AtTTATA 1qnc_B sTkTTATT 6njq_A GTTTATA 6ueo_G TATAAAAG 6ueq_B CTtTTATa 6uer_A cCtTTATA |
| Binding Sites: | 1qn3_E / 6njq_C / 6uer_C 1qn3_F / 6njq_D 1qn4_E 1qn4_F 1qn6_E 1qn6_F 1qn8_E 1qn8_F 1qnb_E 1qnb_F 1qnc_E 1qnc_F 6ueo_H 6ueq_D 1vol_C 1vol_D 6ueo_I / 6uer_D 6ueq_C |
| Publications: | Patikoglou G.A, Kim J.L, Sun L, Yang S.H, Kodadek T, Burley S.K. TATA element recognition by the TATA box-binding protein has been conserved throughout evolution. Genes & development 13:3217-30 (1999). [Pubmed] Nikolov D.B, Chen H, Halay E.D, Usheva A.A, Hisatake K, Lee D.K, Roeder R.G, Burley S.K. Crystal structure of a TFIIB-TBP-TATA-element ternary complex. Nature 377:119-28 (1995). [Pubmed] Stelling AL, Liu AY, Zeng W, Salinas R, Schumacher MA, Al-Hashimi HM. Infrared Spectroscopic Observation of a G-C(+) Hoogsteen Base Pair in the DNA:TATA-Box Binding Protein Complex Under Solution Conditions. Angew Chem Int Ed Engl 58:12010-12013 (2019). [Pubmed] Afek A, Shi H, Rangadurai A, Sahay H, Senitzki A, Xhani S, Fang M, Salinas R, Mielko Z, Pufall MA, Poon GMK, Haran TE, Schumacher MA, Al-Hashimi HM, Gordân R. DNA mismatches reveal conformational penalties in protein-DNA recognition. Nature 587:291-296 (2020). [Pubmed] |
| Related annotations: | PaperBLAST |
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