Transcription Factor
| Accessions: | Q8N9Z0 (JASPAR 2024) |
| Names: | ZN610_HUMAN |
| Organisms: | Homo sapiens |
| Libraries: | JASPAR 2024 1 1 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed] |
| Uniprot: | Q8N9Z0 |
| Length: | 462 |
| Pfam Domains: | 24-64 KRAB box 218-243 Zinc-finger double domain 231-243 C2H2-type zinc finger 232-254 Zinc finger, C2H2 type 232-254 C2H2-type zinc finger 246-270 Zinc-finger double domain 259-279 C2H2-type zinc finger 260-282 Zinc finger, C2H2 type 260-282 C2H2-type zinc finger 274-297 Zinc-finger double domain 287-306 C2H2-type zinc finger 288-310 Zinc finger, C2H2 type 288-308 C2H2-type zinc finger 303-327 Zinc-finger double domain 315-338 C2H2-type zinc finger 316-338 Zinc finger, C2H2 type 316-338 C2H2-type zinc finger 330-354 Zinc-finger double domain 343-354 C2H2-type zinc finger 344-366 Zinc finger, C2H2 type 344-366 C2H2-type zinc finger 359-382 Zinc-finger double domain 371-390 C2H2-type zinc finger 387-410 Zinc-finger double domain 399-410 C2H2-type zinc finger 400-422 Zinc finger, C2H2 type 400-422 C2H2-type zinc finger 415-438 Zinc-finger double domain 427-438 C2H2-type zinc finger 428-450 Zinc finger, C2H2 type 428-449 C2H2-type zinc finger |
| Sequence: (in bold interface residues) | 1 MLCDEEAQKRKAKESGMALPQGRLTFMDVAIEFSQEEWKSLDPGQRALYRDVMLENYRNL 60 61 VFLGICLPDLSIISMLKQRREPLILQSQVKIVKNTDGRECVRSVNTGRSCVLGSNAENKP 120 121 IKNQLGLTLEAHLSELQLFQAGRKIYRSNQVEKFTNHRSSVSPLQKISSSFTTHIFNKYR 180 181 NDLIDFPLLPQEEKAYIRGKSYEYECSEDGEVFRVRASLTNHQVIHTAEKPYKCTECGKV 240 241 FSRNSHLVEHWRIHTGQKPYKCSECDKVFNRNSNLARHQRIHTGEKPHKCNECGKAFREC 300 301 SGLTTHLVIHTGEKPYKCNECGKNFRHKFSLTNHQRSHTAEKPYKCNECGKVFSLLSYLA 360 361 RHQIIHSTEKPYKCNECGRAFHKRPGLMAHLLIHTGEKPYKCNECDKVFGRKLYLTNHQR 420 421 IHTGERPYKCNACGKVFNQNPHLSRHRKIHAGENSLRTLQME |
| Interface Residues: | 115, 118, 215, 217, 221, 232, 242, 243, 244, 245, 246, 248, 249, 251, 252, 253, 255, 270, 271, 272, 273, 274, 276, 277, 278, 281, 298, 299, 300, 301, 302, 303, 304, 305, 306, 309, 326, 327, 328, 329, 330, 332, 333, 354, 355, 356, 357, 358, 359, 360, 361, 382, 383, 384, 385, 386, 388, 389, 395, 409, 410, 411, 412, 413, 414, 417, 421, 438, 439, 440, 441, 442, 445 |
| 3D-footprint Homologues: | 1tau_A, 2gli_A, 7w1m_H, 2kmk_A, 3uk3_C, 8ssq_A, 1f2i_J, 6blw_A, 8ssu_A, 1tf6_A, 5ei9_F, 5kl3_A, 6e94_A, 5yel_A, 2jpa_A, 7n5w_A, 6jnm_A, 5v3j_F, 5kkq_D, 5yj3_D, 4m9v_C, 8h9h_G, 6a57_A, 1ubd_C, 7txc_E, 6ml4_A, 6u9q_A, 1g2f_F, 8cuc_F, 5k5i_A, 7y3l_A, 2drp_D, 7ysf_A, 1tf3_A, 4x9j_A, 2lt7_A, 5k5l_F, 2wbs_A, 8gn3_A, 1llm_D, 7y3m_I |
| Binding Motifs: | MA1713.1 / UN0209.1 sscGCCGCTCCsss MA1713.2 scGCCGCTCC |
| Binding Sites: | MA1713.1.1 / UN0209.1.1 MA1713.1.10 / UN0209.1.10 MA1713.1.11 / UN0209.1.11 MA1713.1.12 / UN0209.1.12 MA1713.1.13 / UN0209.1.13 MA1713.1.14 / UN0209.1.14 MA1713.1.15 / UN0209.1.15 MA1713.1.16 / UN0209.1.16 MA1713.1.17 / UN0209.1.17 MA1713.1.18 / UN0209.1.18 MA1713.1.19 / UN0209.1.19 UN0209.1.2 MA1713.1.20 / UN0209.1.20 MA1713.1.3 / UN0209.1.3 MA1713.1.4 / MA1713.1.7 / UN0209.1.4 / UN0209.1.7 MA1713.1.5 / MA1713.1.6 / MA1713.1.8 / UN0209.1.5 / UN0209.1.6 / UN0209.1.8 MA1713.1.9 / UN0209.1.9 MA1713.1.2 MA1713.2.1 / MA1713.2.11 / MA1713.2.12 / MA1713.2.13 / MA1713.2.14 / MA1713.2.2 / MA1713.2.3 MA1713.2.10 / MA1713.2.17 / MA1713.2.20 / MA1713.2.7 / MA1713.2.8 MA1713.2.15 MA1713.2.16 MA1713.2.18 / MA1713.2.19 / MA1713.2.6 / MA1713.2.9 MA1713.2.4 MA1713.2.5 |
| Publications: | Imbeault M, Helleboid PY, Trono D. KRAB zinc-finger proteins contribute to the evolution of gene regulatory networks. Nature 543:550-554 (2017). [Pubmed] |
| Related annotations: | PaperBLAST |
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These data are available AS IS and at your own risk. The EEAD/CSIC do not give any representation or warranty nor assume any liability or responsibility for the data nor the results posted (whether as to their accuracy, completeness, quality or otherwise). Access to these data is available free of charge for ordinary use in the course of research. Downloaded data have CC-BY-NC-SA license. FootprintDB is also available at RSAT::Plants, part of the INB/ELIXIR-ES resources portfolio.