Transcription Factor

						

			
Accessions: NFKB1_DBD (HumanTF 1.0)

			
Names: E3 SUMO-protein ligase MUL1, E3 ubiquitin-protein ligase MUL1, EC 6.3.2.-, Growth inhibition and death E3 ligase, MAPL, Mitochondrial ubiquitin ligase activator of NFKB 1, Mitochondrial-anchored protein ligase, MUL1_HUMAN, NFKB1, Putative NF-kappa-B-activating protein 266, RING finger protein 218
Organisms: Homo sapiens
Libraries: HumanTF 1.0 1
1 Jolma A, Yan J, Whitington T, Toivonen J, Nitta KR, Rastas P, Morgunova E, Enge M, Taipale M, Wei G, Palin K, Vaquerizas JM, Vincentelli R, Luscombe NM, Hughes TR, Lemaire P, Ukkonen E, Kivioja T, Taipale J. DNA-Binding Specificities of Human Transcription Factors. Cell. 2013 Jan 17;152(1-2):327-39. [Pubmed]
Uniprot: Q969V5
Notes: Ensembl ID: ENSG00000109320; DNA-binding domain sequence; TF family: NFAT; Clone source: Megaman
Length: 345
Pfam Domains:    24-222 Rel homology domain (RHD)
Sequence: 
(in bold interface residues)		   1 THTIFNPEVFQPQMALPTADGPYLQILEQPKQRGFRFRYVCEGPSHGGLPGASSEKNKKS   60
  61 YPQVKICNYVGPAKVIVQLVTNGKNIHLHAHSLVGKHCEDGICTVTAGPKDMVVGFANLG  120
 121 ILHVTKKKVFETLEARMTEACIRGYNPGLLVHPDLAYLQAEGGGDRQLGDREKELIRQAA  180
 181 LQQTKEMDLSVVRLMFTAFLPDSTGSFTRRLEPVVSDAIYDSKAPNASNLKIVRMDRTAG  240
 241 CVTGGEEIYLLCDKVQKDDIQIRFYEEEENGGVWEGFGDFSPTDVHRQFAIVFKTPKYKD  300
 301 INITKPASVFVQLRRKSDLETSEPKPFLYYPEIKDKEEVQRKRQK
Interface Residues: 36, 38, 39, 41, 42, 44, 45, 46, 223, 225, 254, 287, 314, 315
3D-footprint Homologues: 1nfk_A, 9bdw_A, 1a3q_A, 1a66_A, 2o61_A, 1gji_A, 7cli_B, 1p7h_L
Binding Motifs: NFKB1_DBD AGGGGAwTCCCCt
			
Publications: Jolma A, Yan J, Whitington T, Toivonen J, Nitta KR, Rastas P, Morgunova E, Enge M, Taipale M, Wei G, Palin K, Vaquerizas JM, Vincentelli R, Luscombe NM, Hughes TR, Lemaire P, Ukkonen E, Kivioja T, Taipale J. DNA-Binding Specificities of Human Transcription Factors. Cell. 2013 Jan 17;152(1-2):327-39. [Pubmed]
Related annotations: PaperBLAST

	
			


			

				

				
				
				
				

			

			

		

	
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