Transcription Factor

Accessions: 1cf7_A (3D-footprint 20231221)
Names: E2F4_HUMAN, TRANSCRIPTION FACTOR E2F-4, Transcription factor E2F4
Organisms: Homo sapiens
Libraries: 3D-footprint 20231221 1
1 Contreras-Moreira B. 3D-footprint: a database for the structural analysis of protein-DNA complexes. Nucleic acids research 38:D91-7 (2010). [Pubmed]
Uniprot: Q16254
Length: 67
Pfam Domains: 2-67 E2F/DP family winged-helix DNA-binding domain
Sequence:
(in bold interface residues)
1 SRHEKSLGLLTTKFVSLLQEAKDGVLDLKLAADTLAVRQKRRIYDITNVLEGIGLIEKKS 60
61 KNSIQWK
Interface Residues: 2, 39, 40, 41, 42, 44
3D-footprint Homologues: 4yo2_A, 1cf7_A, 1cf7_B
Binding Motifs: 1cf7_A tTcGCGCG
1cf7_AB TCGCGCG
Binding Sites: 1cf7_C
1cf7_D
Publications: Zheng N., Fraenkel E., Pabo C. O., Pavletich N. P. Structural basis of DNA recognition by the heterodimeric cell cycle transcription factor E2F-DP. Genes Dev. 13:666-674 (1999). [Pubmed]
Related annotations: PaperBLAST

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