Transcription Factor

						

			
Accessions: NKX2-3_full (HumanTF 1.0)

			
Names: Homeobox protein NK-2 homolog C, Homeobox protein Nkx-2.3, NKX2-3, NKX23_HUMAN
Organisms: Homo sapiens
Libraries: HumanTF 1.0 1
1 Jolma A, Yan J, Whitington T, Toivonen J, Nitta KR, Rastas P, Morgunova E, Enge M, Taipale M, Wei G, Palin K, Vaquerizas JM, Vincentelli R, Luscombe NM, Hughes TR, Lemaire P, Ukkonen E, Kivioja T, Taipale J. DNA-Binding Specificities of Human Transcription Factors. Cell. 2013 Jan 17;152(1-2):327-39. [Pubmed]
Uniprot: Q8TAU0
Notes: Ensembl ID: ENSG00000119919; Full protein sequence; TF family: homeodomain; Clone source: hORFeome
Length: 365
Pfam Domains:   149-205 Homeobox domain
Sequence: 
(in bold interface residues)		   1 MMLPSPVTSTPFSVKDILNLEQQHQHFHGAHLQADLEHHFHSAPCMLAAAEGTQFSDGGE   60
  61 EDEEDEGEKLSYLNSLAAADGHGDSGLCPQGYVHTVLRDSCSEPKEHEEEPEVVRDRSQK  120
 121 SCQLKKSLETAGDCKAAEESERPKPRSRRKPRVLFSQAQVFELERRFKQQRYLSAPEREH  180
 181 LASSLKLTSTQVKIWFQNRRYKCKRQRQDKSLELGAHAPPPPPRRVAVPVLVRDGKPCVT  240
 241 PSAQAYGAPYSVGASAYSYNSFPAYGYGNSAAAAAAAAAAAAAAAAYSSSYGCAYPAGGG  300
 301 GGGGGTSAATTAMQPACSAAGGGPFVNVSNLGGFGSGGSAQPLHQGTAAGAACAQGTLQG  360
 361 IRAW*
Interface Residues: 120, 148, 149, 150, 151, 152, 190, 191, 193, 194, 197, 198, 200, 201, 202, 205, 236
3D-footprint Homologues: 1au7_A, 5zfz_A, 4j19_B, 3cmy_A, 1puf_A, 3d1n_M, 8pmf_A, 1fjl_B, 5zjt_E, 8ejp_B, 1ig7_A, 6a8r_A, 6m3d_C, 1nk2_P, 1zq3_P, 2lkx_A, 7q3o_C, 6es3_K, 1puf_B, 2ld5_A, 2hdd_A, 8ik5_C, 5jlw_D, 4cyc_A, 2r5y_A, 8eml_B, 1jgg_B, 4xrs_G, 2hos_A, 8osb_E, 5flv_I, 3lnq_A, 3a01_E, 7psx_B, 1b72_A, 5hod_A, 3rkq_B, 9b8u_A, 7xrc_C, 1e3o_C, 2xsd_C, 1le8_A, 1le8_B, 1du0_A, 1mnm_C, 1k61_B, 8bx1_A, 4qtr_D, 8g87_X, 1o4x_A, 4xrm_B, 8f69_A
Binding Motifs: NKX2-3_full asCACTTrav
			
Publications: Jolma A, Yan J, Whitington T, Toivonen J, Nitta KR, Rastas P, Morgunova E, Enge M, Taipale M, Wei G, Palin K, Vaquerizas JM, Vincentelli R, Luscombe NM, Hughes TR, Lemaire P, Ukkonen E, Kivioja T, Taipale J. DNA-Binding Specificities of Human Transcription Factors. Cell. 2013 Jan 17;152(1-2):327-39. [Pubmed]
Related annotations: PaperBLAST

	
			


			

				

				
				
				
				

			

			

		

	
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