Transcription Factor
| Accessions: | DLX5 (HT-SELEX2 May2017) |
| Names: | DLX5, ENSG00000105880 |
| Organisms: | Homo sapiens |
| Libraries: | HT-SELEX2 May2017 1 1 Yin Y, Morgunova E, Jolma A, Kaasinen E, Sahu B, Khund-Sayeed S, Das PK, Kivioja T, Dave K, Zhong F, Nitta KR, Taipale M, Popov A, Ginno PA, Domcke S, Yan J, Schübeler D, Vinson C, Taipale J. Impact of cytosine methylation on DNA binding specificities of human transcription factors. Science : (2017). [Pubmed] |
| Notes: | TF family: Homeodomain experiment: HT-SELEX Hamming distance: 1 cycle: 2, TF family: Homeodomain experiment: Methyl-HT-SELEX Hamming distance: 1 cycle: 1, TF family: Homeodomain experiment: Methyl-HT-SELEX Hamming distance: 1 cycle: 2 |
| Length: | 222 |
| Pfam Domains: | 30-115 Homeobox protein distal-less-like N terminal 136-192 Homeobox domain |
| Sequence: (in bold interface residues) | 1 GVFDRRVPSIRSGDFQAPFQTSAAMHHPSQESPTLPESSATDSDYYSPTGGAPHGYCSPT 60 61 SASYGKALNPYQYQYHGVNGSAGSYPAKAYADYSYASSYHQYGGAYNRVPSATNQPEKEV 120 121 TEPEVRMVNGKPKKVRKPRTIYSSFQLAALQRRFQKTQYLALPERAELAASLGLTQTQVK 180 181 IWFQNKRSKIKKIMKNGEMPPEHSPSSSDPMACNSPQSPAVW |
| Interface Residues: | 136, 137, 138, 139, 177, 178, 180, 181, 184, 185, 188, 189, 192 |
| 3D-footprint Homologues: | 5zjt_E, 2h1k_B, 1puf_A, 1fjl_B, 6a8r_A, 3cmy_A, 1ig7_A, 3d1n_M, 5zfz_A, 1zq3_P, 6m3d_C, 2lkx_A, 1nk2_P, 2ld5_A, 7q3o_C, 6es3_K, 1jgg_B, 5flv_I, 3a01_E, 7psx_B, 1au7_A, 5hod_A, 3lnq_A, 2hdd_A, 1b72_A, 5jlw_D, 3rkq_B, 2r5y_A, 4xrs_G, 2hos_A, 4cyc_A, 1e3o_C, 1le8_A, 7xrc_C, 2xsd_C, 3l1p_A, 1o4x_A, 8g87_X, 4qtr_D, 1k61_B, 4xrm_B, 1puf_B, 1du0_A |
| Binding Motifs: | DLX5_3 syAATTAy DLX5_6 syAATTAy DLX5_methyl_1 gyAATTAt DLX5_methyl_2 vTcrTTAw DLX5_methyl_4 syAATTAy DLX5_methyl_5 vtCrTTAw |
| Related annotations: | PaperBLAST |
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