Transcription Factor

						

			
Accessions: NFATC4 (HT-SELEX2 May2017)

			
Names: ENSG00000100968, NFATC4
Organisms: Homo sapiens
Libraries: HT-SELEX2 May2017 1
1 Yin Y, Morgunova E, Jolma A, Kaasinen E, Sahu B, Khund-Sayeed S, Das PK, Kivioja T, Dave K, Zhong F, Nitta KR, Taipale M, Popov A, Ginno PA, Domcke S, Yan J, Schübeler D, Vinson C, Taipale J. Impact of cytosine methylation on DNA binding specificities of human transcription factors. Science : (2017). [Pubmed]
Notes: TF family: RHD_IPT experiment: HT-SELEX Hamming distance: 1 cycle: 3, TF family: RHD_IPT experiment: HT-SELEX Hamming distance: 1 cycle: 4, TF family: RHD_IPT experiment: Methyl-HT-SELEX Hamming distance: 1 cycle: 3, TF family: RHD_IPT experiment: Methyl-HT-SELEX Hamming distance: 1 cycle: 4
Length: 318
Pfam Domains:    36-195 Rel homology domain (RHD)
  203-299 IPT/TIG domain
Sequence: 
(in bold interface residues)		   1 LAWSKARIGGHSPIFRTSALPPLDWPLPSQYEQLELRIEVQPRAHHRAHYETEGSRGAVK   60
  61 AAPGGHPVVKLLGYSEKPLTLQMFIGTADERNLRPHAFYQVHRITGKMVATASYEAVVSG  120
 121 TKVLEMTLLPENNMAANIDCAGILKLRNSDIELRKGETDIGRKNTRVRLVFRVHVPQGGG  180
 181 KVVSVQAASVPIECSQRSAQELPQVEAYSPSACSVRGGEELVLTGSNFLPDSKVVFIERG  240
 241 PDGKLQWEEEATVNRLQSNEVTLTLTVPEYSNKRVSRPVQVYFYVSNGRRKRSPTQSFRF  300
 301 LPVICKEEPLPDSSLRGF
Interface Residues: 47, 49, 50, 52, 53, 56, 145, 162, 174, 196, 197, 241, 289, 290
3D-footprint Homologues: 1a66_A, 1imh_C, 1p7h_L, 3vw3_L, 3ugm_A, 7cli_B, 1a3q_A, 2ypf_A
Binding Motifs: NFATC4_3 aryGGAAAmw
NFATC4_4 ktTTCCATGGAAam
NFATC4_methyl_1 aayGGAAAmw
NFATC4_methyl_2 ktTTCCryGGAAam
			
Related annotations: PaperBLAST

	
			


			

				

				
				
				
				

			

			

		

	
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