Transcription Factor
| Accessions: | UP00401A (UniPROBE 20160601) |
| Names: | ecotropic viral integration site 16, EVI16, OTTHUMP00000039358, Sox4, SRY (sex determining region Y)-box 4, SRY-related HMG-box gene 4, Transcription factor SOX-4 |
| Organisms: | Homo sapiens |
| Libraries: | UniPROBE 20160601 1 1 Hume MA, Barrera LA, Gisselbrecht SS, Bulyk ML. UniPROBE, update 2015: new tools and content for the online database of protein-binding microarray data on protein-DNA interactions. Nucleic Acids Res : (2015). [Pubmed] |
| Uniprot: | Q06945 |
| Description: | SRY (sex determining region Y)-box 4 : This intronless gene encodes a member of the SOX (SRY-related HMG-box) family of transcription factors involved in the regulation of embryonic development and in the determination of the cell fate. The encoded protein may act as a transcriptional regulator after forming a protein complex with other proteins, such as syndecan binding protein (syntenin). The protein may function |
| Length: | 340 |
| Pfam Domains: | 59-127 HMG (high mobility group) box 60-116 Domain of unknown function (DUF1898) |
| Sequence: (in bold interface residues) | 1 MVQQTNNAENTEALLAGESSDSGAGLELGIASSPTPGSTASTGGKADDPSWCKTPSGHIK 60 61 RPMNAFMVWSQIERRKIMEQSPDMHNAEISKRLGKRWKLLKDSDKIPFIREAERLRLKHM 120 121 ADYPDYKYRPRKKVKSGNANSSSSAAASSKPGEKGDKVGGSGGGGHGGGGGGGSSNAGGG 180 181 GGGASGGGANSKPAQKKSCGSKVAGGAGGGVSKPHAKLILAGGGGGGKAAAAAAASFAAE 240 241 QAGAAALLPLGAAADHHSLYKARTPSASASASSAASASAALAAPGKHLAEKKVKRVYLFG 300 301 GLGTSSSPVGGVGAGADPSDPLGLYEEEGAGCSPDAPSLS |
| Interface Residues: | 61, 64, 66, 67, 70, 74, 85, 86, 87, 90, 128, 130, 132, 142, 147, 148, 151 |
| 3D-footprint Homologues: | 2gzk_A, 2lef_A, 7m5w_A |
| Binding Motifs: | UP00401A_1 tadAACAAwGrvrw |
| Binding Sites: | AAACAAAG AAACAATA AAACAATG AACAAAGA AACAAAGG AACAATAG AACAATGA AACAATGG ACAAAGAA ACAAAGAG ACAAAGGA ACAAAGGG AGACAAAG AGACAATG ATTGTTCC ATTGTTTG CAACAATA CATTGTTC CTTTGTTA CTTTGTTC |
| Publications: | Scharer CD, McCabe CD, Ali-Seyed M, Berger MF, Bulyk ML, Moreno CS. Genome-wide promoter analysis of the SOX4 transcriptional network in prostate cancer. Cancer Research. January 15, 2009. 69(2). [Pubmed] |
| Related annotations: | PaperBLAST |
Disclaimer and license
These data are available AS IS and at your own risk. The EEAD/CSIC do not give any representation or warranty nor assume any liability or responsibility for the data nor the results posted (whether as to their accuracy, completeness, quality or otherwise). Access to these data is available free of charge for ordinary use in the course of research. Downloaded data have CC-BY-NC-SA license. FootprintDB is also available at RSAT::Plants, part of the INB/ELIXIR-ES resources portfolio.