Transcription Factor
| Accessions: | UP00401A (UniPROBE 20160601) |
| Names: | ecotropic viral integration site 16, EVI16, OTTHUMP00000039358, Sox4, SRY (sex determining region Y)-box 4, SRY-related HMG-box gene 4, Transcription factor SOX-4 |
| Organisms: | Homo sapiens |
| Libraries: | UniPROBE 20160601 1 1 Hume MA, Barrera LA, Gisselbrecht SS, Bulyk ML. UniPROBE, update 2015: new tools and content for the online database of protein-binding microarray data on protein-DNA interactions. Nucleic Acids Res : (2015). [Pubmed] |
| Uniprot: | Q06945 |
| Description: | SRY (sex determining region Y)-box 4 : This intronless gene encodes a member of the SOX (SRY-related HMG-box) family of transcription factors involved in the regulation of embryonic development and in the determination of the cell fate. The encoded protein may act as a transcriptional regulator after forming a protein complex with other proteins, such as syndecan binding protein (syntenin). The protein may function |
| Length: | 340 |
| Pfam Domains: | 59-127 HMG (high mobility group) box 60-116 Domain of unknown function (DUF1898) |
| Sequence: (in bold interface residues) | 1 MVQQTNNAENTEALLAGESSDSGAGLELGIASSPTPGSTASTGGKADDPSWCKTPSGHIK 60 61 RPMNAFMVWSQIERRKIMEQSPDMHNAEISKRLGKRWKLLKDSDKIPFIREAERLRLKHM 120 121 ADYPDYKYRPRKKVKSGNANSSSSAAASSKPGEKGDKVGGSGGGGHGGGGGGGSSNAGGG 180 181 GGGASGGGANSKPAQKKSCGSKVAGGAGGGVSKPHAKLILAGGGGGGKAAAAAAASFAAE 240 241 QAGAAALLPLGAAADHHSLYKARTPSASASASSAASASAALAAPGKHLAEKKVKRVYLFG 300 301 GLGTSSSPVGGVGAGADPSDPLGLYEEEGAGCSPDAPSLS |
| Interface Residues: | 61, 64, 66, 67, 70, 74, 75, 85, 86, 87, 90, 128, 130, 132, 142, 147, 148, 151 |
| 3D-footprint Homologues: | 3u2b_C, 1o4x_B, 7m5w_A, 3f27_D, 4s2q_D, 1qrv_A, 3tmm_A, 4y60_C, 2gzk_A, 1j5n_A, 6jrp_D, 2lef_A, 1hry_A, 3tq6_B |
| Binding Motifs: | UP00401A_1 tadAACAAwGrvrw |
| Binding Sites: | AAACAAAG AAACAATA AAACAATG AACAAAGA AACAAAGG AACAATAG AACAATGA AACAATGG ACAAAGAA ACAAAGAG ACAAAGGA ACAAAGGG AGACAAAG AGACAATG ATTGTTCC ATTGTTTG CAACAATA CATTGTTC CTTTGTTA CTTTGTTC |
| Publications: | Scharer CD, McCabe CD, Ali-Seyed M, Berger MF, Bulyk ML, Moreno CS. Genome-wide promoter analysis of the SOX4 transcriptional network in prostate cancer. Cancer Research. January 15, 2009. 69(2). [Pubmed] |
| Related annotations: | PaperBLAST |
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