Transcription Factor
| Accessions: | HOXA1_DBD (HumanTF 1.0), HOXA1_TF2 (HumanTF2 1.0) |
| Names: | Homeobox protein Hox-1F, Homeobox protein Hox-A1, HOXA1, HXA1_HUMAN |
| Organisms: | Homo sapiens |
| Libraries: | HumanTF 1.0 1, HumanTF2 1.0 2 1 Jolma A, Yan J, Whitington T, Toivonen J, Nitta KR, Rastas P, Morgunova E, Enge M, Taipale M, Wei G, Palin K, Vaquerizas JM, Vincentelli R, Luscombe NM, Hughes TR, Lemaire P, Ukkonen E, Kivioja T, Taipale J. DNA-Binding Specificities of Human Transcription Factors. Cell. 2013 Jan 17;152(1-2):327-39. [Pubmed] 2 Jolma A, Yin Y, Nitta KR, Dave K, Popov A, Taipale M, Enge M, Kivioja T, Morgunova E, Taipale J. DNA-dependent formation of transcription factor pairs alters their binding specificity. Nature 527:384-8 (2015). [Pubmed] |
| Uniprot: | P49639 |
| Notes: | Ensembl ID: ENSG00000105991; DNA-binding domain sequence; TF family: homeodomain; Clone source: MGC, Ensembl ID: ENSG00000105991; Construct type: TF2(3xFLAG); TF family: Homeodomain; Clone source: Jolma et al. 2013 |
| Length: | 121 |
| Pfam Domains: | 37-90 Homeobox domain |
| Sequence: (in bold interface residues) | 1 MASSPAQTFDWMKVKRNPPKTGKVGEYGYLGQPNAVRTNFTTKQLTELEKEFHFNKYLTR 60 61 ARRVEIAASLQLNETQVKIWFQNRRMKQKKREKEGLLPISPATPPGNDEKAEESSEKSSS 120 121 S |
| Interface Residues: | 35, 36, 37, 38, 75, 76, 78, 79, 82, 83, 86, 87, 90 |
| 3D-footprint Homologues: | 1zq3_P, 2lkx_A, 6es3_K, 7q3o_C, 5jlw_D, 3rkq_B, 2r5y_A, 1puf_B, 1fjl_B, 4xrs_G, 3d1n_M, 2hos_A, 1b72_A, 5zfz_A, 4cyc_A, 1ig7_A, 6m3d_C, 5flv_I, 2ld5_A, 3a01_E, 2h1k_B, 1jgg_B, 7psx_B, 5hod_A, 3lnq_A, 1puf_A, 6a8r_A, 3cmy_A, 2hdd_A, 1nk2_P, 1le8_A, 1au7_A, 7xrc_C, 2xsd_C, 4j19_B, 1e3o_C, 3l1p_A, 1o4x_A, 8g87_X, 1du0_A, 5zjt_E, 4qtr_D |
| Binding Motifs: | HOXA1_DBD rsyAATTArs ELK1_HOXA1_1 aCCGGAAGTAAtTa ELK1_HOXA1_2 rCCGGAAGTvaTya PBX4_HOXA1 vymATmAATCA- |
| Publications: | Jolma A, Yan J, Whitington T, Toivonen J, Nitta KR, Rastas P, Morgunova E, Enge M, Taipale M, Wei G, Palin K, Vaquerizas JM, Vincentelli R, Luscombe NM, Hughes TR, Lemaire P, Ukkonen E, Kivioja T, Taipale J. DNA-Binding Specificities of Human Transcription Factors. Cell. 2013 Jan 17;152(1-2):327-39. [Pubmed] Jolma A, Yin Y, Nitta KR, Dave K, Popov A, Taipale M, Enge M, Kivioja T, Morgunova E, Taipale J. DNA-dependent formation of transcription factor pairs alters their binding specificity. Nature 527:384-8 (2015). [Pubmed] |
| Related annotations: | PaperBLAST |
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