Transcription Factor
| Accessions: | Q9BYN7 (JASPAR 2024) |
| Names: | ZN341_HUMAN |
| Organisms: | Homo sapiens |
| Libraries: | JASPAR 2024 1 1 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed] |
| Uniprot: | Q9BYN7 |
| Length: | 854 |
| Pfam Domains: | 52-78 C2H2-type zinc finger 322-344 C2H2-type zinc finger 323-344 Zinc finger, C2H2 type 323-344 C2H2-type zinc finger 336-360 Zinc-finger double domain 350-372 Zinc finger, C2H2 type 350-372 C2H2-type zinc finger 445-467 C2H2-type zinc finger 479-497 C2H2-type zinc finger 503-525 C2H2-type zinc finger 503-525 C2H2-type zinc finger 503-525 Zinc finger, C2H2 type 566-586 C2H2-type zinc finger 566-578 C2H2-type zinc finger 609-632 Zinc-finger double domain 622-644 C2H2-type zinc finger 622-644 Zinc finger, C2H2 type 637-665 Zinc-finger double domain 650-677 C2H2-type zinc finger 650-677 Zinc finger, C2H2 type 670-694 Zinc-finger double domain 682-705 C2H2-type zinc finger 683-705 C2H2-type zinc finger 683-705 Zinc finger, C2H2 type 697-721 Zinc-finger double domain |
| Sequence: (in bold interface residues) | 1 MAQAIFEALEGMDNQTVLAVQSLLDGQGAVPDPTGQSVNAPPAIQPLDDEDVFLCGKCKK 60 61 QFNSLPAFMTHKREQCQGNAPALATVSLATNSIYPPSAAPTAVQQAPTPANRQISTYITV 120 121 PPSPLIQTLVQGNILVSDDVLMSAMSAFTSLDQPMPQGPPPVQSSLNMHSVPSYLTQPPP 180 181 PPPPPPPLPPPPPPQPPPPPPQSLGPPGRPNPGGNGVVEVYSAAAPLAGSGTVEIQALGM 240 241 QPYPPLEVPNQCVEPPVYPTPTVYSPGKQGFKPKGPNPAAPMTSATGGTVATFDSPATLK 300 301 TRRAKGARGLPEAAGKPKAQKLKCSYCDKSFTKNFDLQQHIRSHTGEKPFQCIACGRAFA 360 361 QKSNVKKHMQTHKVWPPGHSGGTVSRNSVTVQVMALNPSRQEDEESTGLGQPLPGAPQPQ 420 421 ALSTAGEEEGDKPESKQVVLIDSSYLCQFCPSKFSTYFQLKSHMTQHKNEQVYKCVVKSC 480 481 AQTFPKLDTFLEHIKSHQEELSYRCHLCGKDFPSLYDLGVHQYSHSLLPQHSPKKDNAVY 540 541 KCVKCVNKYSTPEALEHHLQTATHNFPCPHCQKVFPCERYLRRHLPTHGSGGRFKCQVCK 600 601 KFFRREHYLKLHAHIHSGEKPYKCSVCESAFNRKDKLKRHMLIHEPFKKYKCPFSTHTGC 660 661 SKEFNRPDKLKAHILSHSGMKLHKCALCSKSFSRRAHLAEHQRAHTGNYKFRCAGCAKGF 720 721 SRHKYLKDHRCRLGPQKDKDLQTRRPPQRRAAPRSCGSGGRKVLTPLPDPLGLEELKDTG 780 781 AGLVPEAVPGKPPFAEPDAVLSIVVGGAVGAETELVVPGHAEGLGSNLALAELQAGAEGP 840 841 CAMLAVPVYIQASE |
| Interface Residues: | 332, 333, 334, 335, 336, 339, 340, 360, 361, 362, 363, 364, 365, 366, 367, 368, 371, 387, 390, 425, 427, 428, 431, 486, 488, 489, 492, 513, 514, 515, 516, 517, 520, 550, 551, 552, 553, 554, 556, 560, 576, 577, 578, 579, 580, 582, 583, 604, 605, 606, 607, 608, 610, 611, 613, 614, 617, 622, 632, 633, 634, 635, 636, 637, 638, 639, 643, 665, 666, 667, 668, 669, 672, 675, 694, 695, 696, 697, 700, 706, 721, 722, 723, 724, 725, 728, 732 |
| 3D-footprint Homologues: | 3uk3_C, 8cuc_F, 7y3l_A, 8ssq_A, 6jnm_A, 1f2i_J, 6a57_A, 8ssu_A, 1g2f_F, 5kkq_D, 6u9q_A, 1llm_D, 4m9v_C, 7y3m_I, 7w1m_H, 5v3j_F, 5yel_A, 7n5w_A, 6wmi_A, 6ml4_A, 8gn3_A, 7eyi_G, 8h9h_G, 7ysf_A, 2lt7_A, 2i13_A, 1ubd_C, 5und_A, 5ei9_F, 5k5i_A, 1tf6_A, 6e94_A, 2jpa_A, 2kmk_A, 5yj3_D, 1mey_C, 2drp_D, 2gli_A, 6blw_A, 1tf3_A, 4x9j_A, 7txc_E, 5kl3_A, 2wbs_A |
| Binding Motifs: | MA1655.1 grGAACAGCcas MA1655.2 GAACAGCc |
| Binding Sites: | MA1655.2.6 MA1655.1.1 MA1655.1.10 / MA1655.1.8 MA1655.1.10 / MA1655.1.11 MA1655.1.11 / MA1655.1.12 MA1655.1.13 MA1655.1.14 MA1655.1.15 MA1655.1.16 MA1655.1.17 MA1655.1.16 / MA1655.1.18 MA1655.1.17 / MA1655.1.19 MA1655.1.2 MA1655.1.18 / MA1655.1.20 MA1655.1.3 MA1655.1.4 MA1655.1.5 MA1655.1.6 MA1655.1.7 MA1655.1.8 MA1655.1.9 MA1655.1.12 MA1655.1.14 MA1655.1.15 MA1655.1.19 MA1655.1.20 MA1655.1.4 MA1655.1.9 MA1655.2.1 / MA1655.2.13 / MA1655.2.19 / MA1655.2.5 MA1655.2.10 MA1655.2.11 MA1655.2.12 / MA1655.2.14 / MA1655.2.8 MA1655.2.15 MA1655.2.16 / MA1655.2.17 MA1655.2.18 MA1655.2.2 MA1655.2.20 MA1655.2.3 MA1655.2.4 MA1655.2.7 MA1655.2.9 |
| Publications: | Béziat V, Li J, Lin JX, Ma CS, Li P, Bousfiha A, Pellier I, Zoghi S, Baris S, Keles S, Gray P, Du N, Wang Y, Zerbib Y, Lévy R, Leclercq T, About F, Lim AI, Rao G, Payne K, Pelham SJ, Avery DT, Deenick EK, Pillay B, Chou J, Guery R, Belkadi A, Guérin A, Migaud M, Rattina V, Ailal F, Benhsaien I, Bouaziz M, Habib T, Chaussabel D, Marr N, El-Benna J, Grimbacher B, Wargon O, Bustamante J, Boisson B, Müller-Fleckenstein I, Fleckenstein B, Chandesris MO, Titeux M, Fraitag S, Alyanakian MA, Leruez-Ville M, Picard C, Meyts I, Di Santo JP, Hovnanian A, Somer A, Ozen A, Rezaei N, Chatila TA, Abel L, Leonard WJ, Tangye SG, Puel A, Casanova JL. A recessive form of hyper-IgE syndrome by disruption of ZNF341-dependent STAT3 transcription and activity. Sci Immunol : (2018). [Pubmed] |
| Related annotations: | PaperBLAST |
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