Transcription Factor
| Accessions: | ISX_DBD (HumanTF 1.0), ISX (HT-SELEX2 May2017) |
| Names: | Intestine-specific homeobox, ISX, ISX_HUMAN, RAX-like homeobox, ENSG00000175329 |
| Organisms: | Homo sapiens |
| Libraries: | HumanTF 1.0 1, HT-SELEX2 May2017 2 1 Jolma A, Yan J, Whitington T, Toivonen J, Nitta KR, Rastas P, Morgunova E, Enge M, Taipale M, Wei G, Palin K, Vaquerizas JM, Vincentelli R, Luscombe NM, Hughes TR, Lemaire P, Ukkonen E, Kivioja T, Taipale J. DNA-Binding Specificities of Human Transcription Factors. Cell. 2013 Jan 17;152(1-2):327-39. [Pubmed] 2 Yin Y, Morgunova E, Jolma A, Kaasinen E, Sahu B, Khund-Sayeed S, Das PK, Kivioja T, Dave K, Zhong F, Nitta KR, Taipale M, Popov A, Ginno PA, Domcke S, Yan J, Schübeler D, Vinson C, Taipale J. Impact of cytosine methylation on DNA binding specificities of human transcription factors. Science : (2017). [Pubmed] |
| Uniprot: | Q2M1V0 |
| Notes: | Ensembl ID: ENSG00000175329; DNA-binding domain sequence; TF family: homeodomain; Clone source: Gene synthesis, TF family: Homeodomain experiment: HT-SELEX Hamming distance: 1 cycle: 2, TF family: Homeodomain experiment: HT-SELEX Hamming distance: 1 cycle: 4, TF family: Homeodomain experiment: Methyl-HT-SELEX Hamming distance: 1 cycle: 2, TF family: Homeodomain experiment: Methyl-HT-SELEX Hamming distance: 1 cycle: 4 |
| Length: | 110 |
| Pfam Domains: | 26-82 Homeobox domain |
| Sequence: (in bold interface residues) | 1 GEAAASGSGLEKPPKDQPQEGRKSKRRVRTTFTTEQLHELEKIFHFTHYPDVHIRSQLAA 60 61 RINLPEARVQIWFQNQRAKWRKQEKIGNLGAPQQLSEASVALPTNLDVAG |
| Interface Residues: | 13, 15, 16, 17, 19, 24, 26, 27, 28, 29, 35, 67, 68, 70, 71, 74, 75, 77, 78, 79, 81, 82 |
| 3D-footprint Homologues: | 6dnw_A, 3cmy_A, 1puf_A, 3d1n_M, 8ejp_B, 6a8r_A, 1fjl_B, 8pmf_A, 1ig7_A, 5zfz_A, 2lkx_A, 1jgg_B, 6m3d_C, 3lnq_A, 1nk2_P, 1zq3_P, 6es3_K, 2ld5_A, 7q3o_C, 3rkq_B, 5flv_I, 9b8u_A, 2hdd_A, 5zjt_E, 4cyc_A, 2r5y_A, 8ik5_C, 5hod_A, 2hos_A, 1au7_A, 8osb_E, 1puf_B, 7psx_B, 5jlw_D, 8eml_B, 1b72_A, 4xrs_G, 3a01_E, 1e3o_C, 1le8_A, 2xsd_C, 8g87_X, 1o4x_A, 1du0_A, 8bx1_A, 4qtr_D |
| Binding Motifs: | ISX_DBD_1 yTAATyTAATTAr ISX_DBD_2 cyAATTAr ISX_3 CYAATTAa ISX_6 CYAATTAr ISX_methyl_1 CTAATTAa ISX_methyl_2 ctCrTTAa ISX_methyl_4 cYAATTAr ISX_methyl_5 ctCrTTAa |
| Publications: | Jolma A, Yan J, Whitington T, Toivonen J, Nitta KR, Rastas P, Morgunova E, Enge M, Taipale M, Wei G, Palin K, Vaquerizas JM, Vincentelli R, Luscombe NM, Hughes TR, Lemaire P, Ukkonen E, Kivioja T, Taipale J. DNA-Binding Specificities of Human Transcription Factors. Cell. 2013 Jan 17;152(1-2):327-39. [Pubmed] |
| Related annotations: | PaperBLAST |
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