Transcription Factor
| Accessions: | 1imh_C (3D-footprint 20231221), 1imh_D (3D-footprint 20231221) |
| Names: | NF-AT5, NFAT5_HUMAN, NUCLEAR FACTOR OF ACTIVATED T CELLS 5, Nuclear factor of activated T-cells 5, T-cell transcription factor NFAT5, TonE-binding protein, TonEBP, Tonicity-responsive enhancer-binding protein |
| Organisms: | Homo sapiens |
| Libraries: | 3D-footprint 20231221 1 1 Contreras-Moreira B. 3D-footprint: a database for the structural analysis of protein-DNA complexes. Nucleic acids research 38:D91-7 (2010). [Pubmed] |
| Uniprot: | O94916 |
| Length: | 281 |
| Pfam Domains: | 19-156 Rel homology domain (RHD) 182-278 IPT/TIG domain |
| Sequence: (in bold interface residues) | 1 KKSPMLCGQYPVKSEGKELKIVVQPETQHRARYLTEGSRGSVKDRTQQGFPTVKLEGHNE 60 61 PVVLQVFVGNDSGRVKPHGFYQACRVTGRNTTPCKEVDIEGTTVIEVGLDPSNNMTLAVD 120 121 CVGILKLRNADVEARIGIAGSKKKSTRARLVFRVNIMRKDGSTLTLQTPSSPILCTQPAG 180 181 VPEILKKSLHSCSVKGEEEVFLIGKNFLKGTKVIFQENVSDENSWKSEAEIDMELFHQNH 240 241 LIVKVPPYHDQHITLPVSVGIYVVTNAGRSHDVQPFTYTPD |
| Interface Residues: | 30, 32, 33, 35, 36, 39, 126, 143, 177, 179, 206, 238, 267, 268 |
| 3D-footprint Homologues: | 1imh_C, 2ram_A, 7cli_B, 1a3q_A, 1p7h_L, 1a66_A, 2o61_A, 1nfk_A |
| Binding Motifs: | 1imh_C tTCCa 1imh_CD CnnnnntTCCa |
| Binding Sites: | 1imh_A 1imh_B |
| Publications: | Stroud J.C, Lopez-Rodriguez C, Rao A, Chen L. Structure of a TonEBP-DNA complex reveals DNA encircled by a transcription factor. Nature structural biology 9:90-4 (2002). [Pubmed] |
| Related annotations: | PaperBLAST |
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