Transcription Factor

						

			
Accessions: IRF3_full (HumanTF 1.0)

			
Names: Interferon regulatory factor 3, IRF-3, IRF3, IRF3_HUMAN
Organisms: Homo sapiens
Libraries: HumanTF 1.0 1
1 Jolma A, Yan J, Whitington T, Toivonen J, Nitta KR, Rastas P, Morgunova E, Enge M, Taipale M, Wei G, Palin K, Vaquerizas JM, Vincentelli R, Luscombe NM, Hughes TR, Lemaire P, Ukkonen E, Kivioja T, Taipale J. DNA-Binding Specificities of Human Transcription Factors. Cell. 2013 Jan 17;152(1-2):327-39. [Pubmed]
Uniprot: Q14653
Notes: Ensembl ID: ENSG00000126456; Full protein sequence; TF family: IRF; Clone source: hORFeome
Length: 453
Pfam Domains:     7-111 Interferon regulatory factor transcription factor
  201-326 Interferon-regulatory factor 3
Sequence: 
(in bold interface residues)		   1 MGTPKPRILPWLVSQLDLGQLEGVAWVNKSRTRFRIPWKHGLRQDAQQEDFGIFQAWAEA   60
  61 TGAYVPGRDKPDLPTWKRNFRSALNRKEGLRLAEDRSKDPHDPHKIYEFVNSGVGDFSQP  120
 121 DTSPDTNGGGSTSDTQEDILDELLGNMVLAPLPDPGPPSLAVAPEPCPQPLRSPSLDNPT  180
 181 PFPNLGPSENPLKRLLVPGEEWEFEVTAFYRGRQVFQQTISCPEGLRLVGSEVGDRTLPG  240
 241 WPVTLPDPGMSLTDRGVMSYVRHVLSCLGGGLALWRAGQWLWAQRLGHCHTYWAVSEELL  300
 301 PNSGHGPDGEVPKDKEGGVFDLGPFIVGSWAPRSDYLHGRKRTLTTLCPLVLCGGVMAPG  360
 361 PAVDQEARDGQGCAHVPQGLGRNGPGRGCLLPGEYCGPAHFQQPPTLPHLRPVQGLPAGL  420
 421 GGGHGFPGPWGELSPRSSWCASNPPVPHHLNQ*
Interface Residues: 40, 42, 74, 78, 79, 81, 82, 83, 85, 86
3D-footprint Homologues: 2pi0_B, 1if1_B, 2o61_A, 8hcm_A, 2irf_L, 7oot_B, 8hcl_A
Binding Motifs: IRF3_full ssrrAAmGGAAACCGAAACyr
			
Publications: Jolma A, Yan J, Whitington T, Toivonen J, Nitta KR, Rastas P, Morgunova E, Enge M, Taipale M, Wei G, Palin K, Vaquerizas JM, Vincentelli R, Luscombe NM, Hughes TR, Lemaire P, Ukkonen E, Kivioja T, Taipale J. DNA-Binding Specificities of Human Transcription Factors. Cell. 2013 Jan 17;152(1-2):327-39. [Pubmed]
Related annotations: PaperBLAST

	
			


			

				

				
				
				
				

			

			

		

	
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