Transcription Factor
| Accessions: | TBX20_DBD (HumanTF 1.0), TBX20 (HT-SELEX2 May2017) |
| Names: | T-box protein 20, T-box transcription factor TBX20, TBX20, TBX20_HUMAN, ENSG00000164532 |
| Organisms: | Homo sapiens |
| Libraries: | HumanTF 1.0 1, HT-SELEX2 May2017 2 1 Jolma A, Yan J, Whitington T, Toivonen J, Nitta KR, Rastas P, Morgunova E, Enge M, Taipale M, Wei G, Palin K, Vaquerizas JM, Vincentelli R, Luscombe NM, Hughes TR, Lemaire P, Ukkonen E, Kivioja T, Taipale J. DNA-Binding Specificities of Human Transcription Factors. Cell. 2013 Jan 17;152(1-2):327-39. [Pubmed] 2 Yin Y, Morgunova E, Jolma A, Kaasinen E, Sahu B, Khund-Sayeed S, Das PK, Kivioja T, Dave K, Zhong F, Nitta KR, Taipale M, Popov A, Ginno PA, Domcke S, Yan J, Schübeler D, Vinson C, Taipale J. Impact of cytosine methylation on DNA binding specificities of human transcription factors. Science : (2017). [Pubmed] |
| Uniprot: | Q9UMR3 |
| Notes: | Ensembl ID: ENSG00000164532; DNA-binding domain sequence; TF family: T-box; Clone source: Gene synthesis, TF family: T_box experiment: HT-SELEX Hamming distance: 2 cycle: 3, TF family: T_box experiment: HT-SELEX Hamming distance: 2 cycle: 4, TF family: T_box experiment: Methyl-HT-SELEX Hamming distance: 2 cycle: 3, TF family: T_box experiment: Methyl-HT-SELEX Hamming distance: 2 cycle: 4 |
| Length: | 230 |
| Pfam Domains: | 24-211 T-box |
| Sequence: (in bold interface residues) | 1 SLCTEPLIPTTPIIPSEEMAKIACSLETKELWDKFHELGTEMIITKSGRRMFPTIRVSFS 60 61 GVDPEAKYIVLMDIVPVDNKRYRYAYHRSSWLVAGKADPPLPARLYVHPDSPFTGEQLLK 120 121 QMVSFEKVKLTNNELDQHGHIILNSMHKYQPRVHIIKKKDHTASLLNLKSEEFRTFIFPE 180 181 TVFTAVTAYQNQLITKLKIDSNPFAKGFRDSSRLTDIERESVESLIQKHS |
| Interface Residues: | 49, 187, 188, 198, 204, 207, 208 |
| 3D-footprint Homologues: | 1h6f_B, 4a04_B, 1xbr_B, 5flv_I, 2x6v_A, 6f59_B, 3x1l_D |
| Binding Motifs: | TBX20_DBD_1 AGGTGTgAAsGYGTGA TBX20_DBD_2 AGGTGTGAAwtTcACACcT TBX20_DBD_3 gaaaAGGTGTGAAmk TBX20_3 rAGGTGTGAAwTTCACACCTy TBX20_4 rAGGTGTgArgGTGTGAA TBX20_7 rrgGTGTkArgGYGTgAw TBX20_8 tTcACACCTArGTGTGAa TBX20_methyl_1 wagGTGTGAwwwTCACACcTt TBX20_methyl_2 rAGGTGTkAAsGyGTgAA TBX20_methyl_5 raGGYGTgArgGyGTgAw TBX20_methyl_6 TTcACRCCTArGTGTGAA |
| Publications: | Jolma A, Yan J, Whitington T, Toivonen J, Nitta KR, Rastas P, Morgunova E, Enge M, Taipale M, Wei G, Palin K, Vaquerizas JM, Vincentelli R, Luscombe NM, Hughes TR, Lemaire P, Ukkonen E, Kivioja T, Taipale J. DNA-Binding Specificities of Human Transcription Factors. Cell. 2013 Jan 17;152(1-2):327-39. [Pubmed] |
| Related annotations: | PaperBLAST |
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