Transcription Factor

						

			
Accessions: 1le5_A (3D-footprint 20231221), 1le5_E (3D-footprint 20231221)

			
Names: Nuclear factor NF-kappa-B p65 subunit, Nuclear factor of kappa light polypeptide gene enhancer in B-cells 3, TF65_MOUSE, Transcription factor p65
Organisms: Mus musculus
Libraries: 3D-footprint 20231221 1
1 Contreras-Moreira B. 3D-footprint: a database for the structural analysis of protein-DNA complexes. Nucleic acids research 38:D91-7 (2010). [Pubmed]
Uniprot: Q04207
Length: 274
Pfam Domains:     4-169 Rel homology domain (RHD)
Sequence: 
(in bold interface residues)		   1 MAYVEIIEQPKQRGMRFRYKCEGRSAGSIPGERSTDTTKTHPTIKINGYTGPGTVRISLV   60
  61 TKDPPHRPHPHELVGKDCRDGYYEADLCPDRSIHSFQNLGIQCVKKRDLEQAISQRIQTN  120
 121 NNPFHVPIEEQRGDYDLNAVRLCFQVTVRDPAGRPLLLTPVLSHPIFDNRAPNTAELKIC  180
 181 RVNRNSGSCLGGDEIFLLCDKVQKEDIEVYFTGPGWEARGSFSQADVHRQVAIVFRTPPY  240
 241 ADPSLQAPVRVSMQLRRPSDRELSEPMEFQYLPD
Interface Residues: 16, 18, 19, 21, 22, 24, 25, 26, 118, 170, 172, 201, 229
3D-footprint Homologues: 2ram_A, 1imh_C, 7cli_B, 1a3q_A, 1nfk_A, 1a66_A, 2o61_A, 1gji_A
Binding Motifs: 1le5_E tTCC
1le5_AB TGGAATTTCCC
1le5_EF GGGAantTCC
Binding Sites: 1le5_G
1le5_H
			
Publications: Berkowitz B, Huang D.B, Chen-Park F.E, Sigler P.B, Ghosh G. The x-ray crystal structure of the NF-kappa B p50.p65 heterodimer bound to the interferon beta -kappa B site. The Journal of biological chemistry 277:24694-700 (2002). [Pubmed]
Related annotations: PaperBLAST

	
			


			

				

				
				
				
				

			

			

		

	
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