Transcription Factor
| Accessions: | HXB8_HUMAN (HOCOMOCO 10), P17481 (JASPAR 2024) |
| Names: | Homeobox protein Hox-2.4, Homeobox protein Hox-2D, Homeobox protein Hox-B8, HXB8_HUMAN |
| Organisms: | Homo sapiens |
| Libraries: | HOCOMOCO 10 1, JASPAR 2024 2 1 Kulakovskiy IV, Vorontsov IE, Yevshin IS, Soboleva AV, Kasianov AS, Ashoor H, Ba-Alawi W, Bajic VB, Medvedeva YA, Kolpakov FA, Makeev VJ. HOCOMOCO: expansion and enhancement of the collection of transcription factor binding sites models. Nucleic Acids Res : (2016). [Pubmed] 2 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed] |
| Uniprot: | P17481 |
| Length: | 243 |
| Pfam Domains: | 147-203 Homeobox domain |
| Sequence: (in bold interface residues) | 1 MSSYFVNSLFSKYKTGESLRPNYYDCGFAQDLGGRPTVVYGPSSGGSFQHPSQIQEFYHG 60 61 PSSLSTAPYQQNPCAVACHGDPGNFYGYDPLQRQSLFGAQDPDLVQYADCKLAAASGLGE 120 121 EAEGSEQSPSPTQLFPWMRPQAAAGRRRGRQTYSRYQTLELEKEFLFNPYLTRKRRIEVS 180 181 HALGLTERQVKIWFQNRRMKWKKENNKDKFPSSKCEQEELEKQKLERAPEAADEGDAQKG 240 241 DKK |
| Interface Residues: | 146, 147, 148, 149, 150, 151, 188, 189, 191, 192, 195, 196, 199, 200, 203 |
| 3D-footprint Homologues: | 5zfz_A, 1fjl_B, 2h1k_B, 1puf_A, 1ig7_A, 6a8r_A, 3cmy_A, 1jgg_B, 3d1n_M, 1nk2_P, 1zq3_P, 6m3d_C, 3lnq_A, 2lkx_A, 2ld5_A, 2r5y_A, 1puf_B, 6es3_K, 4xrs_G, 2hos_A, 4cyc_A, 5flv_I, 3l1p_A, 5zjt_E, 3a01_E, 7psx_B, 1b72_A, 5hod_A, 2hdd_A, 7q3o_C, 5jlw_D, 3rkq_B, 7xrc_C, 1e3o_C, 2xsd_C, 1le8_A, 1k61_B, 1o4x_A, 8g87_X, 4qtr_D, 4xrm_B, 1mnm_C, 1du0_A |
| Binding Motifs: | MA1502.1 gymATTAm HXB8_HUMAN.H10MO.C|M01248 TTGATTrATkm MA1502.2 gymATTA |
| Publications: | Berger M.F, Badis G, Gehrke A.R, Talukder S, Philippakis A.A, Peña-Castillo L, Alleyne T.M, Mnaimneh S, Botvinnik O.B, Chan E.T, Khalid F, Zhang W, Newburger D, Jaeger S.A, Morris Q.D, Bulyk M.L, Hughes T.R. Variation in homeodomain DNA binding revealed by high-resolution analysis of sequence preferences. Cell 133:1266-76 (2008). [Pubmed] |
| Related annotations: | PaperBLAST |
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These data are available AS IS and at your own risk. The EEAD/CSIC do not give any representation or warranty nor assume any liability or responsibility for the data nor the results posted (whether as to their accuracy, completeness, quality or otherwise). Access to these data is available free of charge for ordinary use in the course of research. Downloaded data have CC-BY-NC-SA license. FootprintDB is also available at RSAT::Plants, part of the INB/ELIXIR-ES resources portfolio.