Transcription Factor
| Accessions: | UP00505A (UniPROBE 20160601) |
| Names: | 10.5, 10.9, 14.10, 20.35, CG2328, Dmel\CG2328, E(eve), Eve, eve2, Even skipped, l(2)46Ce, l(2)46CFg, l(2)46CFh, l(2)46CFj, l(2)46CFp, l(2)46Cg, Segmentation protein even-skipped, VI |
| Organisms: | Drosophila melanogaster |
| Libraries: | UniPROBE 20160601 1 1 Hume MA, Barrera LA, Gisselbrecht SS, Bulyk ML. UniPROBE, update 2015: new tools and content for the online database of protein-binding microarray data on protein-DNA interactions. Nucleic Acids Res : (2015). [Pubmed] |
| Description: | Even skipped: Even skipped may play a role in determining neuronal identity. It may be directly involved in specifying identity of individual neurons and is required for segmentation; involved in transforming the broad, spatial, aperiodic expression patterns of the gap genes into a system of precise periodic expression patterns of the pair-rule and segmentary polarity genes. |
| Length: | 89 |
| Pfam Domains: | 16-72 Homeobox domain |
| Sequence: (in bold interface residues) | 1 LNGSRGSEIPADPSVRRYRTAFTRDQLGRLEKEFYKENYVSRPRRCELAAQLNLPESTIK 60 61 VWFQNRRMKDKRQRIAVAWPYAAVYSDPA |
| Interface Residues: | 16, 17, 18, 19, 26, 29, 30, 32, 33, 57, 58, 60, 61, 64, 65, 68, 69, 72 |
| 3D-footprint Homologues: | 3cmy_A, 5zfz_A, 1fjl_B, 1puf_A, 1ig7_A, 6a8r_A, 2h1k_B, 1nk2_P, 3d1n_M, 1zq3_P, 3lnq_A, 2lkx_A, 1jgg_B, 2ld5_A, 7q3o_C, 6es3_K, 4xrs_G, 2hdd_A, 3rkq_B, 2r5y_A, 6m3d_C, 5flv_I, 2hos_A, 5zjt_E, 4cyc_A, 7psx_B, 1b72_A, 5hod_A, 3l1p_A, 3a01_E, 1mnm_C, 5jlw_D, 1puf_B, 1yo5_C, 7xrc_C, 1e3o_C, 1au7_A, 2xsd_C, 1le8_A, 1k61_B, 1o4x_A, 8g87_X, 4qtr_D, 1du0_A |
| Binding Motifs: | UP00505A_1 mmtwvasCTAATTAGygrdrct |
| Binding Sites: | GGTAATTA AATAATTA ACTAATTA AGTAATTA ATAATTAA ATAATTAC ATAATTAG ATTAATTA CCTAATTA CTAATTAA CTAATTAC CTAATTAG CTTAATTA GATAATTA GCTAATTA GTAATTAA GTAATTAC GTTAATTA TAATTAGA TTAATTAA |
| Publications: | Busser BW, Shokri L, Jaeger SA, Gisselbrecht SS, Singhania A, Berger MF, Zhou B, Bulyk ML, Michelson AM. Molecular mechanism underlying the regulatory specificity of a Drosophila homeodomain protein that specifies myoblast identity. Development 139:1164-74 (2012). [Pubmed] |
| Related annotations: | PaperBLAST |
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