Transcription Factor

						

			
Accessions: PRRX2_full (HumanTF 1.0)

			
Names: Fragment, Predicted NUP98/PRRX2 fusion protein, PRRX2, Q5ISC7_HUMAN
Organisms: Homo sapiens
Libraries: HumanTF 1.0 1
1 Jolma A, Yan J, Whitington T, Toivonen J, Nitta KR, Rastas P, Morgunova E, Enge M, Taipale M, Wei G, Palin K, Vaquerizas JM, Vincentelli R, Luscombe NM, Hughes TR, Lemaire P, Ukkonen E, Kivioja T, Taipale J. DNA-Binding Specificities of Human Transcription Factors. Cell. 2013 Jan 17;152(1-2):327-39. [Pubmed]
Uniprot: Q5ISC7
Notes: Ensembl ID: ENSG00000167157; Full protein sequence; TF family: homeodomain; Clone source: hORFeome
Length: 254
Pfam Domains:   105-161 Homeobox domain
  227-245 OAR domain
Sequence: 
(in bold interface residues)		   1 MDSAAAAFALDKPALGPGPPPPPPALGPGDCAQARKNFSVSHLLDLEEVAAAGRLAARPG   60
  61 ARAEAREGAAREPSGGSSGSEAAPQDGECPSPGRGSAAKRKKKQRRNRTTFNSSQLQALE  120
 121 RVFERTHYPDAFVREELARRVNLSEARVQVWFQNRRAKFRRNERAMLASRSASLLKSYSQ  180
 181 EAAIEQPVAPRPTALSPDYLSWTASSPYSTVPPYSPGSSGPATPGVNMANSIASLRLKAK  240
 241 EFSLHHSQVPTVN*
Interface Residues: 105, 106, 107, 108, 146, 147, 149, 150, 153, 154, 156, 157, 158, 161
3D-footprint Homologues: 1puf_A, 3d1n_M, 1fjl_B, 8ejp_B, 6a8r_A, 1ig7_A, 3cmy_A, 8pmf_A, 5zfz_A, 3lnq_A, 1nk2_P, 1zq3_P, 2lkx_A, 1jgg_B, 2ld5_A, 7q3o_C, 6es3_K, 2r5y_A, 6m3d_C, 5flv_I, 2hos_A, 9b8u_A, 1au7_A, 5zjt_E, 4j19_B, 1puf_B, 8ik5_C, 7psx_B, 5hod_A, 1b72_A, 3a01_E, 8osb_E, 5jlw_D, 3rkq_B, 8eml_B, 4xrs_G, 2hdd_A, 4cyc_A, 1e3o_C, 1le8_A, 2xsd_C, 7xrc_C, 8g87_X, 8bx1_A, 4qtr_D, 1o4x_A, 1du0_A
Binding Motifs: PRRX2_full yyAATTAr
			
Publications: Jolma A, Yan J, Whitington T, Toivonen J, Nitta KR, Rastas P, Morgunova E, Enge M, Taipale M, Wei G, Palin K, Vaquerizas JM, Vincentelli R, Luscombe NM, Hughes TR, Lemaire P, Ukkonen E, Kivioja T, Taipale J. DNA-Binding Specificities of Human Transcription Factors. Cell. 2013 Jan 17;152(1-2):327-39. [Pubmed]
Related annotations: PaperBLAST

	
			


			

				

				
				
				
				

			

			

		

	
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