Transcription Factor
| Accessions: | STAT2_MOUSE (HOCOMOCO 10), Q9WVL2 (JASPAR 2024) |
| Names: | STAT2_MOUSE |
| Organisms: | Mus musculus |
| Libraries: | HOCOMOCO 10 1, JASPAR 2024 2 1 Kulakovskiy IV, Vorontsov IE, Yevshin IS, Soboleva AV, Kasianov AS, Ashoor H, Ba-Alawi W, Bajic VB, Medvedeva YA, Kolpakov FA, Makeev VJ. HOCOMOCO: expansion and enhancement of the collection of transcription factor binding sites models. Nucleic Acids Res : (2016). [Pubmed] 2 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed] |
| Uniprot: | Q9WVL2 |
| Length: | 923 |
| Pfam Domains: | 2-123 STAT protein, protein interaction domain 139-314 STAT protein, all-alpha domain 316-565 STAT protein, DNA binding domain 576-647 SH2 domain 854-908 Signal transducer and activator of transcription 2 C terminal |
| Sequence: (in bold interface residues) | 1 MAQWEMLQNLDSPFLDQLHQVYSQSFLPMDFRQHLASWIEDQNWREAALESDDAKANMLY 60 61 FSILDQLNQWDHYSSDPKSLLLQHNLRKFSRDIQPFPNGPSQLAEMIFNLLLEEQRILIQ 120 121 AQRAQEVQPPPAPEAVVESQQLEIENRIQGLHVDIEFLVRSIRQLKDEQDVFSFRYTVFS 180 181 LKKTSSSDPHQSQQAHVVQATANKVDRMRKEVLDISKGLVGRLTTLVDLLLPKLDEWKVQ 240 241 QQKSCIGAPPPVKSAAEQLEQWLTAGAKFLFHLRQLLKQLKEMSCLRYQGDMFAKGVDLR 300 301 NAQVMELLQRLLQRSFVVETQPCMPQTLHRPLILKTGNKFTVRTRLLVRLQEGSESLKAE 360 361 VSVDRNSDLPGFRKFNILTSNQKTLTPEKGQRQGLIWDFGFLTLVEQRAVGAGKGNNKGP 420 421 LAVTEELHVISFVVEYTYQGLKMKLQTDTLPVVIISNMNQLSFAWASILWFNMLSPNPKN 480 481 QQFFCQAPKAPWSLLGPVLSWQFSSYVARGLDSEQLGMLRTKLFGKSCKMEDALLSWVDF 540 541 CKRESPPGKIPFWTWLDKILELVHDHLKDLWKDGRIMGFVSRNQERRLLKKMLSGTFLLR 600 601 FSETSEGGITCSWVEHQDDHKVEIYSVQPYTKEVLQSLPLTEIIRHYQVLAEENIPENPL 660 661 RFLYPRIPRDEAFGCYYQEKVNLEEQEEYLKHKLIVISNRQVDELQQPLELKQDSESLEV 720 721 NAELLLAHDQELPLMMQTGLVLGTELKVDPILSTAPQVLLEPAPQVLLEPAPQVLLEPAP 780 781 QVLLEPAPQVLLEPAPQVLLEPAPQVLLEPAPQVQLEPAPQVLLELAPQVLLEPAPQVLL 840 841 ELAPQVQLEPAHLLQQPSESDLPEDLQQISVEDLKKLSNPSTEYITTNENPMLAGESSGD 900 901 ETSIPYHSHFDADGLLGWTLDTF |
| Interface Residues: | 335, 418, 456, 457, 458, 459, 460 |
| 3D-footprint Homologues: | 1bf5_A, 1bg1_A, 4y5w_B |
| Binding Motifs: | STAT2_MOUSE.H10MO.B|M01366 tcasTTTCrkTTyyc MA1623.1 rgAAACAGAAAsw MA1623.2 gAAACAGAAA |
| Binding Sites: | MA1623.1.1 MA1623.1.10 / MA1623.1.7 MA1623.1.11 MA1623.1.12 MA1623.1.13 / MA1623.1.8 MA1623.1.14 / MA1623.1.8 MA1623.1.15 / MA1623.1.9 MA1623.1.16 MA1623.1.10 / MA1623.1.13 / MA1623.1.17 MA1623.1.18 MA1623.1.11 / MA1623.1.19 MA1623.1.2 MA1623.1.20 MA1623.1.3 MA1623.1.3 / MA1623.1.4 MA1623.1.4 / MA1623.1.5 MA1623.1.5 / MA1623.1.6 MA1623.1.7 MA1623.1.6 / MA1623.1.9 MA1623.1.12 MA1623.1.15 MA1623.1.16 MA1623.1.17 MA1623.1.18 MA1623.1.19 MA1623.1.20 MA1623.2.10 / MA1623.2.13 MA1623.2.1 / MA1623.2.12 / MA1623.2.2 MA1623.2.11 / MA1623.2.14 / MA1623.2.17 / MA1623.2.3 / MA1623.2.6 / MA1623.2.7 / MA1623.2.8 MA1623.2.15 / MA1623.2.5 MA1623.2.16 MA1623.2.18 MA1623.2.19 MA1623.2.20 MA1623.2.4 MA1623.2.9 |
| Publications: | Martinez-Moczygemba M, Gutch MJ, French DL, Reich NC. Distinct STAT structure promotes interaction of STAT2 with the p48 subunit of the interferon-alpha-stimulated transcription factor ISGF3. J Biol Chem 272:20070-6 (1997). [Pubmed] |
| Related annotations: | PaperBLAST |
Disclaimer and license
These data are available AS IS and at your own risk. The EEAD/CSIC do not give any representation or warranty nor assume any liability or responsibility for the data nor the results posted (whether as to their accuracy, completeness, quality or otherwise). Access to these data is available free of charge for ordinary use in the course of research. Downloaded data have CC-BY-NC-SA license. FootprintDB is also available at RSAT::Plants, part of the INB/ELIXIR-ES resources portfolio.