Transcription Factor

						

			
Accessions: 5t0u_A (3D-footprint 20231221)

			
Names: 11-zinc finger protein, CCCTC-binding factor, CTCF_HUMAN, CTCFL paralog, Transcriptional repressor CTCF
Organisms: Homo sapiens
Libraries: 3D-footprint 20231221 1
1 Contreras-Moreira B. 3D-footprint: a database for the structural analysis of protein-DNA complexes. Nucleic acids research 38:D91-7 (2010). [Pubmed]
Uniprot: P49711
Length: 170
Pfam Domains:      2-24 Zinc finger, C2H2 type
     2-24 C2H2-type zinc finger
    17-41 Zinc-finger double domain
    30-53 Zinc finger, C2H2 type
    30-53 C2H2-type zinc finger
    45-68 Zinc-finger double domain
    59-81 C2H2-type zinc-finger domain
    59-81 C2H2-type zinc finger
    74-95 Zinc-finger double domain
   87-110 C2H2-type zinc-finger domain
   87-109 Zinc finger, C2H2 type
   87-109 C2H2-type zinc finger
  102-126 Zinc-finger double domain
  115-138 C2H2-type zinc finger
  145-168 Zinc finger, C2H2 type
  145-168 C2H2-type zinc finger
Sequence: 
(in bold interface residues)		   1 THKCHLCGRAFRTVTLLRNHLNTHTGTRPHKCPDCDMAFVTSGELVRHRRYKHTHEKPFK   60
  61 CSMCDYASVEVSKLKRHIRSHTGERPFQCSLCSYASRDTYKLKRHMRTHSGEKPYECYIC  120
 121 HARFTQSGTMKMHILQKHTENVAKFHCPHCDTVIARKSDLGVHLRKQHSY
Interface Residues: 12, 13, 14, 15, 16, 18, 19, 40, 41, 42, 43, 44, 46, 47, 49, 50, 51, 54, 69, 70, 71, 72, 73, 76, 77, 94, 96, 97, 98, 99, 100, 101, 102, 103, 104, 105, 112, 125, 126, 127, 128, 129, 131, 132, 133, 136, 156, 157, 158, 159, 162, 165
3D-footprint Homologues: 7w1m_H, 5v3j_F, 6wmi_A, 2kmk_A, 2lt7_A, 2i13_A, 6e94_A, 1ubd_C, 7n5w_A, 6jnm_A, 8ssu_A, 1mey_C, 5kkq_D, 5ei9_F, 5yj3_D, 8ssq_A, 7eyi_G, 7ysf_A, 6a57_A, 2jpa_A, 7y3l_A, 1tf3_A, 6ml4_A, 4x9j_A, 6blw_A, 1f2i_J, 6u9q_A, 5kl3_A, 1g2f_F, 1tf6_A, 5und_A, 2gli_A, 8h9h_G, 4m9v_C, 3uk3_C, 8cuc_F, 8gn3_A, 2wbs_A, 7txc_E, 5k5i_A, 1llm_D, 7y3m_I, 1yuj_A, 2drp_D, 5yel_A, 5k5l_F
Binding Motifs: 5t0u_A CaGCAGGGGGCGc
Binding Sites: 5t0u_B
5t0u_C
			
Publications: Hashimoto H, Wang D, Horton JR, Zhang X, Corces VG, Cheng X. Structural Basis for the Versatile and Methylation-Dependent Binding of CTCF to DNA. Mol Cell 66:711-720 (2017). [Pubmed]
Related annotations: PaperBLAST

	
			


			

				

				
				
				
				

			

			

		

	
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