Transcription Factor
| Accessions: | UP00614B (UniPROBE 20160601) |
| Names: | NBLST2, NBPhox, Neuroblastoma Phox, paired mesoderm homeobox protein 2B, Paired-like homeobox 2B, PHOX2B homeodomain protein, PHOX2B_Q143R, PMX2B |
| Organisms: | Homo sapiens |
| Libraries: | UniPROBE 20160601 1 1 Hume MA, Barrera LA, Gisselbrecht SS, Bulyk ML. UniPROBE, update 2015: new tools and content for the online database of protein-binding microarray data on protein-DNA interactions. Nucleic Acids Res : (2015). [Pubmed] |
| Description: | paired mesoderm homeobox protein 2B: The DNA-associated protein encoded by this gene is a member of the paired family of homeobox proteins localized to the nucleus. The protein functions as a transcription factor involved in the development of several major noradrenergic neuron populations and the determination of neurotransmitter phenotype. The gene product is linked to enhancement of second messenger-mediated activation of the dopamine beta-hydroylase, c-fos promoters and several enhancers, including cy |
| Length: | 86 |
| Pfam Domains: | 15-71 Homeobox domain |
| Sequence: (in bold interface residues) | 1 LFTDHGGLNEKRKQRRIRTTFTSAQLKELERVFAETHYPDIYTREELALKIDLTEARVRV 60 61 WFQNRRAKFRKQERAAAAAAAAAKNG |
| Interface Residues: | 14, 15, 16, 17, 18, 56, 57, 59, 60, 63, 64, 67, 68, 71 |
| 3D-footprint Homologues: | 1nk2_P, 1ig7_A, 2h1k_B, 1puf_A, 6a8r_A, 3cmy_A, 1fjl_B, 3d1n_M, 5zfz_A, 1zq3_P, 6m3d_C, 1jgg_B, 3lnq_A, 2lkx_A, 2ld5_A, 7q3o_C, 6es3_K, 5flv_I, 3l1p_A, 5zjt_E, 4j19_B, 3a01_E, 7psx_B, 5hod_A, 2hdd_A, 1au7_A, 5jlw_D, 3rkq_B, 2r5y_A, 1puf_B, 4xrs_G, 2hos_A, 1b72_A, 4cyc_A, 2xsd_C, 1e3o_C, 1le8_A, 7xrc_C, 1o4x_A, 8g87_X, 1du0_A, 4qtr_D |
| Binding Motifs: | UP00614B_1 wsvgakssTAATTAgsmawwwmw |
| Binding Sites: | GGTAATTA AATTAGCG ACCAATTA ACTAATTA AGTAATTA ATAATTAG ATAATTAT ATAATTGG ATTAATTA CATAATTA CCTAATTA CGTAATTA CTAATTAC CTAATTAG GATAATTA GCTAATTA GTAATTAC TTAATTAA CAATTATG CCAATTAC |
| Publications: | Barrera LA, Vedenko A, Kurland JV, Rogers JM, Gisselbrecht SS, Rossin EJ, Woodard J, Mariani L, Kock KH, Inukai S, Siggers T, Shokri L, Gordân R, Sahni N, Cotsapas C, Hao T, Yi S, Kellis M, Daly MJ, Vidal M, Hill DE, Bulyk ML. Survey of variation in human transcription factors reveals prevalent DNA binding changes. Science 351:1450-4 (2016). [Pubmed] |
| Related annotations: | PaperBLAST |
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