Transcription Factor
Accessions: | 4l18_F (3D-footprint 20231221), 5zmc_B (3D-footprint 20231221) |
Names: | ETS1_HUMAN, p54, Protein C-ets-1 |
Organisms: | Homo sapiens |
Libraries: | 3D-footprint 20231221 1 1 Contreras-Moreira B. 3D-footprint: a database for the structural analysis of protein-DNA complexes. Nucleic acids research 38:D91-7 (2010). [Pubmed] |
Uniprot: | P14921 |
Length: | 106 |
Pfam Domains: | 4-85 Ets-domain |
Sequence: (in bold interface residues) | 1 SGPIQLWQFLLELLTDKSCQSFISWTGDGWEFKLSDPDEVARRWGKRKNKPKMNYEKLSR 60 61 GLRYYYDKNIIHKTAGKRYVYRFVCDLQSLLGYTPEELHAMLDVKP |
Interface Residues: | 1, 34, 38, 39, 42, 56, 57, 59, 60, 61, 63, 64, 78 |
3D-footprint Homologues: | 3zp5_A, 2wbs_A, 4mhg_A, 1dux_F, 4uno_A, 3jtg_A, 7jsa_J, 2stt_A, 8ee9_F, 4iri_A, 4l18_B, 1yo5_C, 1awc_A, 4lg0_B, 4bqa_A, 1bc8_C |
Binding Motifs: | 4l18_EF AGGATGTGGCTT 5zmc_B CTTCCG |
Binding Sites: | 4l18_G 4l18_H 5zmc_C 5zmc_D |
Publications: | Shrivastava T, Mino K, Babayeva N.D, Baranovskaya O.I, Rizzino A, Tahirov T.H. Structural basis of Ets1 activation by Runx1. Leukemia 28:2040-8 (2014). [Pubmed] Xu X, Li Y, Bharath SR, Ozturk MB, Bowler MW, Loo BZL, Tergaonkar V, Song H. Structural basis for reactivating the mutant TERT promoter by cooperative binding of p52 and ETS1. Nat Commun 9:3183 (2018). [Pubmed] |
Related annotations: | PaperBLAST |
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These data are available AS IS and at your own risk. The EEAD/CSIC do not give any representation or warranty nor assume any liability or responsibility for the data nor the results posted (whether as to their accuracy, completeness, quality or otherwise). Access to these data is available free of charge for ordinary use in the course of research. Downloaded data have CC-BY-NC-SA license. FootprintDB is also available at RSAT::Plants, part of the INB/ELIXIR-ES resources portfolio.