Transcription Factor

						

			
Accessions: FOXP3 (HT-SELEX2 May2017)

			
Names: ENSG00000049768, FOXP3
Organisms: Homo sapiens
Libraries: HT-SELEX2 May2017 1
1 Yin Y, Morgunova E, Jolma A, Kaasinen E, Sahu B, Khund-Sayeed S, Das PK, Kivioja T, Dave K, Zhong F, Nitta KR, Taipale M, Popov A, Ginno PA, Domcke S, Yan J, Schübeler D, Vinson C, Taipale J. Impact of cytosine methylation on DNA binding specificities of human transcription factors. Science : (2017). [Pubmed]
Notes: TF family: Forkhead experiment: HT-SELEX Hamming distance: 2 cycle: 4, TF family: Forkhead experiment: Methyl-HT-SELEX Hamming distance: 2 cycle: 4
Length: 441
Pfam Domains:   287-334 Fork head domain
  392-425 Fork head domain
Sequence: 
(in bold interface residues)		   1 MSPISGASPSWRAAPKASDLLGARGPGGTFQGRDLRGGAHASSSSLNPMPPSQLQLSTVD   60
  61 AHARTPVLQVHPLESPAMISLTPPTTATGVFSLKARPGLPPGINVASLEWVSREPALLCT  120
 121 FPNPSAPRKDSTLSAVPQSSYPLLANGVCKWPGCEKVFEEPEDFLKHCQADHLLDEKGRA  180
 181 QCLLQREMVQSLEQQLVLEKEKLSAMQAHLAGKMALTKASSVASSDKGSCCIVAAGSQGP  240
 241 VVPAWSGPREAPDSLFAVRRHLWGSHGNSTFPEFLHNMDYFKFHNMRPPFTYATLIRWAI  300
 301 LEAPEKQRTLNEIYHWFTRMFAFFRNHPATWKVSSSEVAVTGMASSAIAAQSGQAWVWAH  360
 361 RHIGEERDVGCWWWLLASEVDAHLLPVPGLPQNAIRHNLSLHKCFVRVESEKGAVWTVDE  420
 421 LEFRKKRSQRPSRCSNPTPGP
Interface Residues: 160, 161, 162, 163, 166, 327, 330, 332, 333, 334, 393, 394, 396, 397, 398, 400, 401
3D-footprint Homologues: 2jpa_A, 5kl3_A, 3l2c_A, 7vox_H, 2hdc_A, 7yz7_A, 7yzb_A, 2c6y_A, 7vou_C, 7yze_A, 7yzg_A, 6nce_A, 2a07_J, 7cby_C, 2uzk_A, 6ako_C, 3co6_C, 6el8_A
Binding Motifs: FOXP3_2 sAWTTGTATGACAAATs
FOXP3_methyl_1 bAwTTGTATGAYRAATs
			
Related annotations: PaperBLAST

	
			


			

				

				
				
				
				

			

			

		

	
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