Transcription Factor

Accessions: Q9HBE1 (JASPAR 2024)
Names: BTB/POZ domain zinc finger transcription factor, PATZ1_HUMAN, POZ-, AT hook-, and zinc finger-containing protein 1, Protein kinase A RI subunit alpha-associated protein, Zinc finger and BTB domain-containing protein 19, Zinc finger protein 278, Zinc finger sarcoma gene protein
Organisms: Homo sapiens
Libraries: JASPAR 2024 1
1 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed]
Uniprot: Q9HBE1
Length: 687
Pfam Domains: 30-159 BTB/POZ domain
293-314 C2H2-type zinc finger
356-377 C2H2-type zinc finger
357-377 Zinc finger, C2H2 type
369-394 Zinc-finger double domain
383-405 Zinc finger, C2H2 type
383-405 C2H2-type zinc finger
398-423 Zinc-finger double domain
413-436 Zinc finger, C2H2 type
413-436 C2H2-type zinc finger
427-453 Zinc-finger double domain
442-464 C2H2-type zinc finger
496-514 Zinc-finger of C2H2 type
497-517 Zinc finger, C2H2 type
497-518 C2H2-type zinc finger
605-628 C2H2-type zinc finger
605-628 Zinc finger, C2H2 type
Sequence:
(in bold interface residues)
1 MERVNDASCGPSGCYTYQVSRHSTEMLHNLNQQRKNGGRFCDVLLRVGDESFPAHRAVLA 60
61 ACSEYFESVFSAQLGDGGAADGGPADVGGATAAPGGGAGGSRELEMHTISSKVFGDILDF 120
121 AYTSRIVVRLESFPELMTAAKFLLMRSVIEICQEVIKQSNVQILVPPARADIMLFRPPGT 180
181 SDLGFPLDMTNGAALAANSNGIAGSMQPEEEAARAAGAAIAGQASLPVLPGVDRLPMVAG 240
241 PLSPQLLTSPFPSVASSAPPLTGKRGRGRPRKANLLDSMFGSPGGLREAGILPCGLCGKV 300
301 FTDANRLRQHEAQHGVTSLQLGYIDLPPPRLGENGLPISEDPDGPRKRSRTRKQVACEIC 360
361 GKIFRDVYHLNRHKLSHSGEKPYSCPVCGLRFKRKDRMSYHVRSHDGSVGKPYICQSCGK 420
421 GFSRPDHLNGHIKQVHTSERPHKCQTCNASFATRDRLRSHLACHEDKVPCQVCGKYLRAA 480
481 YMADHLKKHSEGPSNFCSICNRGFSSASYLKVHVKTHHGVPLPQVSRHQEPILNGGAAFH 540
541 CARTYGNKEGQKCSHQDPIESSDSYGDLSDASDLKTPEKQSANGSFSCDMAVPKNKMESD 600
601 GEKKYPCPECGSFFRSKSYLNKHIQKVHVRALGGPLGDLGPALGSPFSPQQNMSLLESFG 660
661 FQIVQSAFASSLVDPEVDQQPMGPEGK
Interface Residues: 306, 330, 332, 333, 348, 351, 352, 365, 366, 367, 368, 369, 371, 372, 373, 393, 394, 395, 396, 397, 398, 399, 400, 401, 403, 404, 416, 420, 421, 423, 424, 425, 426, 427, 428, 429, 430, 434, 452, 453, 454, 455, 456, 458, 459, 478, 479, 480, 481, 484, 505, 506, 508, 509, 512, 534, 535, 536, 537, 539, 540, 542, 565, 566, 567, 570, 575, 588, 591, 592, 594, 598, 615, 616, 617, 618, 619, 622, 649
3D-footprint Homologues: 5yel_A, 1yuj_A, 7y3l_A, 7n5w_A, 3uk3_C, 6jnm_A, 8cuc_F, 6ml4_A, 2jpa_A, 8gn3_A, 6blw_A, 5kkq_D, 6u9q_A, 5ei9_F, 2kmk_A, 7txc_E, 5kl3_A, 2gli_A, 6wmi_A, 5k5i_A, 1ubd_C, 7w1m_H, 5und_A, 1mey_C, 8ssu_A, 8h9h_G, 4m9v_C, 7eyi_G, 1tf3_A, 7y3m_I, 1tf6_A, 6e94_A, 7ysf_A, 2lt7_A, 8ssq_A, 2i13_A, 6a57_A, 1f2i_J, 4x9j_A, 2drp_D, 1g2f_F, 5yj3_D, 2wbs_A, 3gox_A, 5v3j_F, 1llm_D, 5k5l_F
Binding Motifs: MA1961.1 ssGGGGmGGGGs
MA1961.2 sGGGGmGGGGs
Publications: Ow JR, Ma H, Jean A, Goh Z, Lee YH, Chong YM, Soong R, Fu XY, Yang H, Wu Q. Patz1 regulates embryonic stem cell identity. Stem Cells Dev 23:1062-73 (2014). [Pubmed]
Related annotations: PaperBLAST

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