Transcription Factor
| Accessions: | UP00612B (UniPROBE 20160601) |
| Names: | FLJ37460, Hup1, paired box protein Pax-7, PAX7_P112L, PAX7B, RMS2 |
| Organisms: | Homo sapiens |
| Libraries: | UniPROBE 20160601 1 1 Hume MA, Barrera LA, Gisselbrecht SS, Bulyk ML. UniPROBE, update 2015: new tools and content for the online database of protein-binding microarray data on protein-DNA interactions. Nucleic Acids Res : (2015). [Pubmed] |
| Description: | paired box protein Pax-7: This gene is a member of the paired box (PAX) family of transcription factors. Members of this gene family typically contain a paired box domain, an octapeptide, and a paired-type homeodomain. These genes play critical roles during fetal development and cancer growth. The specific function of the paired box 7 gene is unknown but speculated to involve tumor suppression since fusion of this gene with a forkhead domain family member has been associated with alveolar rhabdomyosarcoma |
| Length: | 155 |
| Pfam Domains: | 15-140 'Paired box' domain |
| Sequence: (in bold interface residues) | 1 YPRTGFPLEVSTPLGQGRVNQLGGVFINGRPLPNHIRHKIVEMAHHGIRPCVISRQLRVS 60 61 HGCVSKILCRYQETGSIRPGAIGGSKPRQVATLDVEKKIEEYKRENPGMFSWEIRDRLLK 120 121 DGHCDRSTVPSVSSISRVLRIKFGKKEEEDEADKK |
| Interface Residues: | 28, 60, 61, 63, 65, 66, 82, 85, 88, 131, 132, 133, 134, 136, 137, 140 |
| 3D-footprint Homologues: | 1k78_A, 1pdn_C, 6pax_A |
| Binding Motifs: | UP00612B_1 gmawwtaACCGTGACsrawwav |
| Binding Sites: | CGTTCCGC AACCGTGA ACCATGAC ACCGTAAC ACCGTGAC ACCGTGTC AGCGTGAC CCATGACG CCGTCACG CCGTGACC CCGTGACG CGGTCACG CGTCACGC CGTGACCA CGTGACGA CGTTACGC GCCGTGAC GCGTGACC GGCGTGAC TACCGTGA |
| Publications: | Barrera LA, Vedenko A, Kurland JV, Rogers JM, Gisselbrecht SS, Rossin EJ, Woodard J, Mariani L, Kock KH, Inukai S, Siggers T, Shokri L, Gordân R, Sahni N, Cotsapas C, Hao T, Yi S, Kellis M, Daly MJ, Vidal M, Hill DE, Bulyk ML. Survey of variation in human transcription factors reveals prevalent DNA binding changes. Science 351:1450-4 (2016). [Pubmed] |
| Related annotations: | PaperBLAST |
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