Transcription Factor
| Accessions: | Q8IYI8 (JASPAR 2024) |
| Names: | ZN440_HUMAN |
| Organisms: | Homo sapiens |
| Libraries: | JASPAR 2024 1 1 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed] |
| Uniprot: | Q8IYI8 |
| Length: | 595 |
| Pfam Domains: | 4-44 KRAB box 164-181 Zinc-finger double domain 173-194 C2H2-type zinc finger 174-194 Zinc finger, C2H2 type 174-183 C2H2-type zinc finger 187-210 Zinc-finger double domain 199-212 C2H2-type zinc finger 217-239 Zinc-finger double domain 229-250 C2H2-type zinc finger 244-266 Zinc-finger double domain 270-295 Zinc-finger double domain 284-306 C2H2-type zinc finger 284-294 C2H2-type zinc finger 300-320 Zinc-finger double domain 311-334 C2H2-type zinc finger 312-334 Zinc finger, C2H2 type 312-334 C2H2-type zinc finger 327-349 Zinc-finger double domain 339-358 C2H2-type zinc finger 340-362 Zinc finger, C2H2 type 340-362 C2H2-type zinc finger 355-378 Zinc-finger double domain 367-390 C2H2-type zinc finger 368-390 C2H2-type zinc finger 368-390 Zinc finger, C2H2 type 382-406 Zinc-finger double domain 395-414 C2H2-type zinc finger 396-418 C2H2-type zinc finger 396-418 Zinc finger, C2H2 type 410-434 Zinc-finger double domain 423-442 C2H2-type zinc finger 424-445 C2H2-type zinc finger 424-448 Zinc finger, C2H2 type 447-468 Zinc-finger double domain 458-480 C2H2-type zinc finger 473-489 Zinc-finger double domain |
| Sequence: (in bold interface residues) | 1 MDPVAFKDVAVNFTQEEWALLDISQRKLYREVMLETFRNLTSLGKRWKDQNIEYEHQNPR 60 61 RNFRSLIEEKVNEIKDDSHCGETFTPVPDDRLNFQEKKASPEVKSCESFVCGEVGLGNSS 120 121 FNMNIRGDIGHKAYEYQEYGPKPCKCQQPKKAFRYRPSFRTQERDHTGEKPNACKVCGKT 180 181 FISHSSVRRHMVMHSGDGPYKCKFCGKAFHCLRLYLIHERIHTGEKPCECKQCGKSFSYS 240 241 ATHRIHKRTHTGEKPYEYQECGKAFHSPRSYRRHERIHMGEKAYQCKECGKAFTCPRYVR 300 301 IHERTHSRKNLYECKQCGKALSSLTSFQTHVRLHSGERPYECKICGKDFCSVNSFQRHEK 360 361 IHSGEKPYKCKQCGKAFPHSSSLRYHERTHTGEKPYECKQCGKAFRSASHLRVHGRTHTG 420 421 EKPYECKECGKAFRYVNNLQSHERTQTHIRIHSGERRYKCKICGKGFYCPKSFQRHEKTH 480 481 TGEKLYECKQRSVVPSVVPVPFDIMKGLTLERSPINASNVGKPSELCQSFECMVGLTLKR 540 541 NPMSVSNDGKPSDLPHTFEYVVGHTMERSPMHVRNVGNPSDLPRTFEFMKGHKHT |
| Interface Residues: | 157, 161, 182, 186, 211, 212, 214, 217, 221, 239, 241, 242, 245, 267, 269, 270, 273, 295, 296, 297, 298, 301, 312, 323, 324, 325, 326, 329, 332, 348, 349, 350, 351, 353, 354, 356, 357, 359, 360, 361, 363, 377, 378, 379, 380, 381, 382, 384, 385, 388, 389, 406, 407, 408, 409, 410, 412, 413, 414, 417, 434, 435, 436, 437, 438, 439, 440, 441, 443, 444, 445, 448, 468, 469, 470, 471, 472, 474, 475 |
| 3D-footprint Homologues: | 7w1m_H, 8ssu_A, 8ssq_A, 5v3j_F, 2drp_D, 6wmi_A, 2kmk_A, 6ml4_A, 8gn3_A, 1tf6_A, 7eyi_G, 5yel_A, 5und_A, 6blw_A, 5kkq_D, 2lt7_A, 2i13_A, 6e94_A, 7ysf_A, 2jpa_A, 1ubd_C, 6jnm_A, 8cuc_F, 1tf3_A, 7y3l_A, 7n5w_A, 1mey_C, 1f2i_J, 5k5i_A, 2gli_A, 1g2f_F, 4x9j_A, 5kl3_A, 2wbs_A, 5ei9_F, 8h9h_G, 7y3m_I, 6a57_A, 3uk3_C, 6u9q_A, 1llm_D, 7txc_E, 5yj3_D, 4m9v_C |
| Binding Motifs: | UN0615.1 arTkGTTCTGCt |
| Related annotations: | PaperBLAST |
Disclaimer and license
These data are available AS IS and at your own risk. The EEAD/CSIC do not give any representation or warranty nor assume any liability or responsibility for the data nor the results posted (whether as to their accuracy, completeness, quality or otherwise). Access to these data is available free of charge for ordinary use in the course of research. Downloaded data have CC-BY-NC-SA license. FootprintDB is also available at RSAT::Plants, part of the INB/ELIXIR-ES resources portfolio.