Transcription Factor

Accessions: NFKB2 (HT-SELEX2 May2017)
Names: ENSG00000077150, NFKB2
Organisms: Homo sapiens
Libraries: HT-SELEX2 May2017 1
1 Yin Y, Morgunova E, Jolma A, Kaasinen E, Sahu B, Khund-Sayeed S, Das PK, Kivioja T, Dave K, Zhong F, Nitta KR, Taipale M, Popov A, Ginno PA, Domcke S, Yan J, Schübeler D, Vinson C, Taipale J. Impact of cytosine methylation on DNA binding specificities of human transcription factors. Science : (2017). [Pubmed]
Notes: TF family: RHD_IPT experiment: HT-SELEX Hamming distance: 1 cycle: 4, TF family: RHD_IPT experiment: Methyl-HT-SELEX Hamming distance: 1 cycle: 4
Length: 332
Pfam Domains: 24-204 Rel homology domain (RHD)
Sequence:
(in bold interface residues)
1 DFKLNSSIVEPKEPAPETADGPYLVIVEQPKQRGFRFRYGCEGPSHGGLPGASSEKGRKT 60
61 YPTVKICNYEGPAKIEVDLVTHSDPPRAHAHSLVGKQCSELGICAVSVGPKDMTAQFNNL 120
121 GVLHVTKKNMMGTMIQKLQRQRLRSRPQGLTEAEQRELEQEAKELKKVMDLSIVRLRFSA 180
181 FLRASDGSFSLPLKPVISQPIHDSKSPGASNLKISRMDKTAGSVRGGDEVYLLCDKVQKD 240
241 DIEVRFYEDDENGWQAFGDFSPTDVHKQYAIVFRTPPYHKMKIERPVTVFLQLKRKRGGD 300
301 VSDSKQFTYYPLVEDKEEVQRKRRKALPTFSQ
Interface Residues: 36, 38, 39, 41, 42, 44, 45, 46, 205, 207, 236, 267
3D-footprint Homologues: 1nfk_A, 1a3q_A, 2o61_A, 1gji_A, 2ram_A, 1imh_C, 7cli_B
Binding Motifs: NFKB2_2 rGGGGAWgymCCk
NFKB2_methyl_1 aGGGrAWkyMCCk
Related annotations: PaperBLAST

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