Transcription Factor

						

			
Accessions: TFE3 (SMILE-seq 1.0)

			
Names: bHLHe33, Class E basic helix-loop-helix protein 33, TFE3, TFE3_HUMAN, TFE3_MOUSE, Transcription factor E3
Organisms: Homo sapiens, Mus musculus
Libraries: SMILE-seq 1.0 1
1 Isakova A, Groux R, Imbeault M, Rainer P, Alpern D, Dainese R, Ambrosini G, Trono D, Bucher P, Deplancke B. SMiLE-seq identifies binding motifs of single and dimeric transcription factors. Nat Methods 14:316-322 (2017). [Pubmed]
Uniprot: Q64092
Notes: TF family: bHLH; TF family: 
Length: 536
Pfam Domains:   311-364 Helix-loop-helix DNA-binding domain
  396-536 Domain of unknown function (DUF3371)
Sequence: 
(in bold interface residues)		   1 MSHAAEPARDAVEASAEGPRAVFLLLEERRPAESAQLLSLNSLLPESGIVADIELENILD   60
  61 PDSFYELKSQPLSLRSSLPISLQATPTTPATLSASSSAGGSRTPAMSSSSSRVLLRQQLM  120
 121 RAQAQEQERRERREQAAAAPFPSPAPASPAISVIGVSAGGHTLSRPPPAQVPREVLKVQT  180
 181 HLENPTRYHLQQARRQQVKQYLSTTLGPKLASQALTPPPGPSSAQPLPAPETAHATGPTG  240
 241 SAPNSPMALLTIGSSSEKELPVSGNLLDVYSSQGVATPAITVSNSCPAELPNIKREISET  300
 301 EAKALLKERQKKDNHNLIERRRRFNINDRIKELGTLIPKSNDPEMRWNKGTILKASVDYI  360
 361 RKLQKEQQRSKDLESRQRSLEQANRSLQLRIQELELQAQIHGLPVPPNPGLLSLTTSSVS  420
 421 DSLKPEQLDIEEEGRPSTTFHVSGGPAQNAPPQQPPAPPSDALLDLHFPSDHLGDLGDPF  480
 481 HLGLEDILMEEEGMVGGLSGGALSPLRAASDPLLSSVSPAVSKASSRRSSFSMEEE
Interface Residues: 240, 242, 244, 245, 249, 312, 315, 316, 318, 319, 322, 323, 347, 349
3D-footprint Homologues: 5l6l_D, 1a0a_B, 7ssa_L, 4h10_A, 6g1l_A, 5gnj_I, 7xi3_A, 5nj8_D, 4h10_B, 7d8t_A, 5i50_B, 8osl_O, 5v0l_A, 4zpk_A, 7f2f_B, 5eyo_A, 1am9_A, 2ypa_B, 8osl_P, 1an4_A, 2ypa_A, 5nj8_C, 5v0l_B
Binding Motifs: TFE3 CACGTGAy
			
Publications: Isakova A, Groux R, Imbeault M, Rainer P, Alpern D, Dainese R, Ambrosini G, Trono D, Bucher P, Deplancke B. SMiLE-seq identifies binding motifs of single and dimeric transcription factors. Nat Methods 14:316-322 (2017). [Pubmed]
Related annotations: PaperBLAST

	
			


			

				

				
				
				
				

			

			

		

	
Disclaimer and license


These data are available AS IS and at your own risk. The EEAD/CSIC do not give any representation or warranty nor assume any liability or responsibility for the data nor the results posted (whether as to their accuracy, completeness, quality or otherwise). Access to these data is available free of charge for ordinary use in the course of research. Downloaded data have CC-BY-NC-SA license. FootprintDB is also available at RSAT::Plants, part of the INB/ELIXIR-ES resources portfolio.