Transcription Factor
| Accessions: | LHX6_full (HumanTF 1.0) |
| Names: | LHX6, LHX6_HUMAN, LIM homeobox protein 6, LIM/homeobox protein Lhx6, LIM/homeobox protein Lhx6.1 |
| Organisms: | Homo sapiens |
| Libraries: | HumanTF 1.0 1 1 Jolma A, Yan J, Whitington T, Toivonen J, Nitta KR, Rastas P, Morgunova E, Enge M, Taipale M, Wei G, Palin K, Vaquerizas JM, Vincentelli R, Luscombe NM, Hughes TR, Lemaire P, Ukkonen E, Kivioja T, Taipale J. DNA-Binding Specificities of Human Transcription Factors. Cell. 2013 Jan 17;152(1-2):327-39. [Pubmed] |
| Uniprot: | Q9UPM6 |
| Notes: | Ensembl ID: ENSG00000106852; Full protein sequence; TF family: homeodomain; Clone source: hORFeome |
| Length: | 393 |
| Pfam Domains: | 99-156 LIM domain 160-214 LIM domain 249-305 Homeobox domain |
| Sequence: (in bold interface residues) | 1 MYWKHENAAPALPEGCRLPAEGGPATDQVMAQPGSGCKATTRCLEGTAPPAMAQSDAEAL 60 61 AGALDKDEGQASPCTPSTPSVCSPPSAASSVPSAGKNICSSCGLEILDRYLLKVNNLIWH 120 121 VRCLECSVCRTSLRQQNSCYIKNKEIFCKMDYFSRFGTKCARCGRQIYASDWVRRARGNA 180 181 YHLACFACFSCKRQLSTGEEFGLVEEKVLCRIHYDTMIENLKRAAENGNGLTLEGAVPSE 240 241 QDSQPKPAKRARTSFTAEQLQVMQAQFAQDNNPDAQTLQKLADMTGLSRRVIQVWFQNCR 300 301 ARHKKHTPQHPVPPSGAPPSRLPSALSDDIHYTPFSSPERARMVTLHGYIESQVQCGQVH 360 361 CRLPYTAPPVHLKADMDGPLSNRGEKVILFQY* |
| Interface Residues: | 249, 250, 251, 252, 290, 291, 293, 294, 297, 298, 301, 302, 305 |
| 3D-footprint Homologues: | 1fjl_B, 3d1n_M, 1ig7_A, 6a8r_A, 2h1k_B, 1puf_A, 3cmy_A, 5zfz_A, 6m3d_C, 1nk2_P, 1zq3_P, 1jgg_B, 3lnq_A, 2lkx_A, 2ld5_A, 7q3o_C, 6es3_K, 2r5y_A, 1puf_B, 5flv_I, 2hos_A, 5zjt_E, 1b72_A, 4cyc_A, 7psx_B, 5hod_A, 3l1p_A, 3a01_E, 5jlw_D, 4xrs_G, 2hdd_A, 3rkq_B, 2xsd_C, 1e3o_C, 7xrc_C, 1o4x_A, 1du0_A, 4qtr_D, 1le8_B |
| Binding Motifs: | LHX6_full_1 rcTAATTAry LHX6_full_2 TAATTAGyryTrATTR LHX6_full_3 TRATTGCAATyA |
| Publications: | Jolma A, Yan J, Whitington T, Toivonen J, Nitta KR, Rastas P, Morgunova E, Enge M, Taipale M, Wei G, Palin K, Vaquerizas JM, Vincentelli R, Luscombe NM, Hughes TR, Lemaire P, Ukkonen E, Kivioja T, Taipale J. DNA-Binding Specificities of Human Transcription Factors. Cell. 2013 Jan 17;152(1-2):327-39. [Pubmed] |
| Related annotations: | PaperBLAST |
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