Transcription Factor
| Accessions: | ECK120005767 (RegulonDB 7.5) |
| Names: | NrdR |
| Organisms: | ECK12 |
| Libraries: | RegulonDB 7.5 1 1 Salgado H, Peralta-Gil M, Gama-Castro S, Santos-Zavaleta A, Muniz-Rascado L, Garcia-Sotelo JS, Weiss V, Solano-Lira H, Martinez-Flores I, Medina-Rivera A, Salgado-Osorio G, Alquicira-Hernandez S, Alquicira-Hernandez K, Lopez-Fuentes A, Porron-Sotelo L, Huerta AM, Bonavides-Martinez C, Balderas-Martinez YI, Pannier L, Olvera M, Labastida A, Jimenez-Jacinto V, Vega-Alvarado L, Del Moral-Chavez V, Hernandez-Alvarez A, Morett E, Collado-Vides J. RegulonDB v8.0: omics data sets, evolutionary conservation, regulatory phrases, cross-validated gold standards and more. Nucleic Acids Res. 2013 Jan 1;41(D1):D203-D213. [Pubmed] |
| Notes: | NrdR is a zinc finger/ATP cone transcriptional regulatory protein that regulates the expression of several operonsencoding ribonucleotide reductases; The protein binds Zn2+ and contains ATP/dATPTorrents E,2007.NrdR was first identified as a potential regulator of ribonucleotide reductase genes by phylogenetic profilingRodionov DA,2005.nrdR is expressed at similar levels during exponential and stationary phase growth and is not required forgrowth Torrents E,2007.NrdR: nrd regulation Rodionov DA,2005Review: Herrick J,2007; repressor; metal ion binding; ATP binding; negative regulation of transcription, DNA-dependent; transcription repressor activity; double-stranded DNA binding; nucleotide binding |
| Length: | 150 |
| Pfam Domains: | 50-136 ATP cone domain |
| Sequence: (in bold interface residues) | 1 MHCPFCFAVDTKVIDSRLVGEGSSVRRRRQCLVCNERFTTFEVAELVMPRVVKSNDVREP 60 61 FNEEKLRSGMLRALEKRPVSSDDVEMAINHIKSQLRATGEREVPSKMIGNLVMEQLKKLD 120 121 KVAYIRFASVYRSFEDIKEFGEEIARLED* |
| Interface Residues: | 15, 17, 40, 41, 42, 47, 77 |
| 3D-footprint Homologues: | 7p3f_A, 2lt7_A |
| Binding Motifs: | NrdR cACwAyATmTwGsrktk |
| Binding Sites: | ECK120033054 ECK120033056 ECK120033058 ECK120033060 ECK120033062 ECK120033064 |
| Publications: | Rodionov DA., Gelfand MS. Identification of a bacterial regulatory system for ribonucleotide reductases by phylogenetic profiling. Trends Genet. 21(7):385-9 (2005). [Pubmed] Herrick J., Sclavi B. Ribonucleotide reductase and the regulation of DNA replication: an old story and an ancient heritage. Mol Microbiol. 63(1):22-34 (2007). [Pubmed] Torrents E., Grinberg I., Gorovitz-Harris B., Lundstrom H., Borovok I., Aharonowitz Y., Sjoberg BM., Cohen G. NrdR controls differential expression of the Escherichia coli ribonucleotide reductase genes. J Bacteriol. 189(14):5012-21 (2007). [Pubmed] |
| Related annotations: | PaperBLAST |
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