Transcription Factor
| Accessions: | LHX5 (HT-SELEX2 May2017), Q9H2C1 (JASPAR 2024) |
| Names: | ENSG00000089116, LHX5, LHX5_HUMAN, LIM homeobox protein 5, LIM/homeobox protein Lhx5 |
| Organisms: | Homo sapiens |
| Libraries: | HT-SELEX2 May2017 1, JASPAR 2024 2 1 Yin Y, Morgunova E, Jolma A, Kaasinen E, Sahu B, Khund-Sayeed S, Das PK, Kivioja T, Dave K, Zhong F, Nitta KR, Taipale M, Popov A, Ginno PA, Domcke S, Yan J, Schübeler D, Vinson C, Taipale J. Impact of cytosine methylation on DNA binding specificities of human transcription factors. Science : (2017). [Pubmed] 2 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed] |
| Notes: | TF family: Znf_LIM_Homeodomain experiment: HT-SELEX Hamming distance: 1 cycle: 3, TF family: Znf_LIM_Homeodomain experiment: Methyl-HT-SELEX Hamming distance: 1 cycle: 3 |
| Length: | 402 |
| Pfam Domains: | 5-60 LIM domain 64-121 LIM domain 181-237 Homeobox domain 203-232 Homeobox KN domain |
| Sequence: (in bold interface residues) | 1 MMVHCAGCERPILDRFLLNVLDRAWHIKCVQCCECKTNLSEKCFSREGKLYCKNDFFRRF 60 61 GTKCAGCAQGISPSDLVRKARSKVFHLNCFTCMVCNKQLSTGEELYVIDENKFVCKDDYL 120 121 SSSSLKEGSLNSVSSCTDRSLSPDLQDALQDDPKETDNSTSSDKETANNENEEQNSGTKR 180 181 RGPRTTIKAKQLETLKAAFAATPKPTRHIREQLAQETGLNMRVIQVWFQNRRSKERRMKQ 240 241 LSALGARRHAFFRSPRRMRPLGGRLDESEMLGSTPYTYYGDYQGDYYAPGSNYDFFAHGP 300 301 PSQAQSPADSSFLAASGPGSTPLGALEPPLAGPHAADNPRFTDMISHPDTPSPEPGLPGT 360 361 LHPMPGEVFSGGPSPPFPMSGTSGYSGPLSHPNPELNEAAVW |
| Interface Residues: | 178, 180, 181, 182, 183, 184, 222, 223, 225, 226, 229, 230, 233, 234, 236, 237, 247 |
| 3D-footprint Homologues: | 1puf_A, 2ld5_A, 4j19_B, 3a01_E, 1fjl_B, 5zfz_A, 2lkx_A, 1ig7_A, 5zjt_E, 3cmy_A, 1mnm_C, 7psx_B, 6a8r_A, 3d1n_M, 1zq3_P, 1nk2_P, 5jlw_D, 1k61_B, 4cyc_A, 1au7_A, 4xrs_G, 3l1p_A, 2h1k_B, 6m3d_C, 1b72_A, 5flv_I, 3lnq_A, 2hdd_A, 5hod_A, 3rkq_B, 2r5y_A, 1puf_B, 1jgg_B, 2hos_A, 1e3o_C, 2xsd_C, 7xrc_C, 1le8_A, 7q3o_C, 6es3_K, 1o4x_A, 8g87_X, 4qtr_D, 1du0_A, 4xrm_B |
| Binding Motifs: | LHX5_3 / MA1519.1 sYAATTAa LHX5_methyl_1 syAATTAa LHX5_methyl_2 ctCRTTAw MA1519.2 sYAATTA |
| Publications: | Berger M.F, Badis G, Gehrke A.R, Talukder S, Philippakis A.A, Peña-Castillo L, Alleyne T.M, Mnaimneh S, Botvinnik O.B, Chan E.T, Khalid F, Zhang W, Newburger D, Jaeger S.A, Morris Q.D, Bulyk M.L, Hughes T.R. Variation in homeodomain DNA binding revealed by high-resolution analysis of sequence preferences. Cell 133:1266-76 (2008). [Pubmed] |
| Related annotations: | PaperBLAST |
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