Transcription Factor
| Accessions: | UP00477A (UniPROBE 20160601), P47043 (JASPAR 2024) |
| Names: | Zap1, Zinc-responsive Activator Protein, ZRG10, ZAP1_YEAST |
| Organisms: | Saccharomyces cerevisiae |
| Libraries: | UniPROBE 20160601 1, JASPAR 2024 2 1 Hume MA, Barrera LA, Gisselbrecht SS, Bulyk ML. UniPROBE, update 2015: new tools and content for the online database of protein-binding microarray data on protein-DNA interactions. Nucleic Acids Res : (2015). [Pubmed] 2 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed] |
| Description: | Zinc-responsive Activator Protein : Zinc-regulated transcription factor; binds to zinc-responsive promoters to induce transcription of certain genes in presence of zinc, represses other genes in low zinc; regulates its own transcription; contains seven zinc-finger domains |
| Length: | 880 |
| Pfam Domains: | 706-730 C2H2-type zinc finger 738-762 Zinc finger, C2H2 type 738-762 C2H2-type zinc finger 744-763 C2H2-type zinc finger 755-778 Zinc-finger double domain 767-791 C2H2-type zinc finger 768-790 Zinc finger, C2H2 type 783-806 Zinc-finger double domain 795-811 C2H2-type zinc finger 796-818 Zinc finger, C2H2 type 796-818 C2H2-type zinc finger 810-834 Zinc-finger double domain 824-846 C2H2-type zinc finger 825-846 C2H2-type zinc finger 825-846 Zinc finger, C2H2 type 838-859 Zinc-finger double domain 850-862 C2H2-type zinc finger |
| Sequence: (in bold interface residues) | 1 MDALTPRDSPKRDDSMATSAATAASAKPDALTIGKEGIVHGHIHNYNNLTYIHGHLHHSA 60 61 PVNDSSASATPAAAAVADAATSAFASGASHDMGGDCHVNEKCKEYTDCQHFEFLNYHNNP 120 121 SLTKYNDTATYNSNNHSFANNFHSVASDPTSPQQNSKSDLPRRKDSWFNDDLILLPSSKK 180 181 NKPNPPPGSDDCYCTPKILEICCDETHPKSEANIKQGESDQPTKKDISENGNDVAIFTDV 240 241 KNDHLMPNFNLHDQYCNSTNHDSHNHNNTVPDSFSQLMSHLSEIDCDLTCDTPCTASTSA 300 301 TSGHKFVQDHQSSNNDDVFHKYCKFCEESTDNQPCSKHMHLESKPPQLPPKCSSLRKPTN 360 361 TLQGTNHAYHEHILNTDMDLKILEDLCNISSLYEVPFGKHINHHDHNNAGNGCDGSSTGN 420 421 NENGNQTMNLLLSSINRCNPKNNLNGSNNNTAGATSTDHQHHHHRIQFHSHKPNRNNIVN 480 481 NSGISAANTTADLTNNDLNDLISREYSYERFRNQSEPPSLPKVTHQNQKNRRSWPTKDLE 540 541 STDFSSLEDSLPSSISPPIQTTSTINFNWCFKEEKNNDLKCKWKECPESCSSLFDLQRHL 600 601 LKDHVSQDFKHPMEPLACNWEDCDFLGDDTCSIVNHINCQHGINFDIQFANPDSFLPGSI 660 661 SKEKHHLLHCPNPQTHEVSKADGAPDMTSANDVSNIPPIKQPEQVICQWDGCNKSFSSAQ 720 721 ELNDHLEAVHLTRGKSEYQCLWHDCHRTFPQRQKLIRHLKVHSKYKPYKCKTCKRCFSSE 780 781 ETLVQHTRTHSGEKPYKCHICNKKFAISSSLKIHIRTHTGEKPLQCKICGKRFNESSNLS 840 841 KHIKTHQKKYKCSDCSKSFDDLGKLNSQKVKCALERKPYL |
| Interface Residues: | 718, 720, 721, 723, 724, 726, 727, 733, 750, 751, 752, 753, 754, 757, 761, 768, 778, 779, 780, 781, 782, 784, 785, 806, 807, 808, 809, 810, 811, 812, 813, 814, 834, 835, 836, 837, 838, 839, 840, 841, 842, 845, 861, 862, 863, 864, 867 |
| 3D-footprint Homologues: | 5v3j_F, 2i13_A, 5yel_A, 6wmi_A, 2jpa_A, 1tf3_A, 7w1m_H, 2gli_A, 8ssu_A, 1tf6_A, 6ml4_A, 5kkq_D, 5ei9_F, 8ssq_A, 7eyi_G, 6e94_A, 7ysf_A, 1ubd_C, 2kmk_A, 7n5w_A, 3uk3_C, 6jnm_A, 1g2f_F, 4x9j_A, 6blw_A, 6u9q_A, 1mey_C, 5kl3_A, 5und_A, 8h9h_G, 2lt7_A, 5k5i_A, 6a57_A, 8cuc_F, 7y3l_A, 5k5l_F, 8gn3_A, 1llm_D, 2wbs_A, 7txc_E, 2drp_D, 1f2i_J, 4m9v_C, 7y3m_I, 5yj3_D |
| Binding Motifs: | UP00477A_1 / UP00477A_2 ktrrmwACCCTaadGGTymssa UP00477A_3 GGTTAy MA0440.1 ACCyTmArGGTyrTG |
| Binding Sites: | AAGGTTAC AGAGGTTA AGGGTTAC AAAGGTTA AAGGGTTA AAGGTTAT AGGGGTTA AGGGTTAT AGGTTACC AGGTTATG ATAACCCC ATAACCTC CAGGGTTA CATAACCC CCATAACC CGGGGTTA CGTAACCC GAGGTTAC GGGTTATA GGTTATGA |
| Publications: | Gordân R, Murphy KF, McCord RP, Zhu C, Vedenko A, Bulyk ML. Curated collection of yeast transcription factor DNA binding specificity data reveals novel structural and gene regulatory insights. Genome Biol : (2011). [Pubmed] MacIsaac K.D, Wang T, Gordon D.B, Gifford D.K, Stormo G.D, Fraenkel E. An improved map of conserved regulatory sites for Saccharomyces cerevisiae. BMC bioinformatics 7:113 (2006). [Pubmed] |
| Related annotations: | PaperBLAST |
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