Transcription Factor

						

			
Accessions: brk (DrosophilaTF 1.1), Q9XTN4 (JASPAR 2024)

			
Names: Brinker, Brk, Putative transcription factor, Q9XTN4_DROME, RE18244p
Organisms: Drosophila melanogaster
Libraries: DrosophilaTF 1.1 1, JASPAR 2024 2
1 Down T.A, Bergman C.M, Su J, Hubbard T.J. Large-scale discovery of promoter motifs in Drosophila melanogaster. PLoS computational biology 3:e7 (2007). [Pubmed]

2 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed]
Uniprot: Q9XTN4
Length: 704
Pfam Domains:    43-100 Brinker DNA-binding domain
    52-89 Helix-turn-helix domain
Sequence: 
(in bold interface residues)		   1 MDSSSEQLNGSGALNFKRPKDSSENATNSHTNNGNSSGSPKMGSRRIFTPHFKLQVLESY   60
  61 RNDNDCKGNQRATARKYNIHRRQIQKWLQCESNLRSSVANNQQQQQQQQQQQQQQQQQQQ  120
 121 LLPQQSVSPTPAVKVFHQLSHPLVHQLHHHHAAAVGHHHHHAAHHHAAHHHHAAAAAAAA  180
 181 AAAAAAAAAHHHAAHHLLAANGMVPHPLAAHPHLHVPVAMHPQMQHQKEQQQQQQQLQQE  240
 241 QQQQDQQQSQQETPATIATNGSNQGSSNVLSAAKIAAVVAAAMATSNGNPTPTATIPASS  300
 301 SSSSNTLPSSNNSSCHNSSSSSNSCNSNQVPIQVPILSGSPGSTSSASHIPHVPFAYHHN  360
 361 LHGYLENRLEAVATPAPMDLSLGSSARRQMQLHEKDPSGVDLTFRKRKVITSPMQPDKIS  420
 421 KLEEVIKKEPETETENEDVEVDVETEQPEEHKLPSKQVKLFKPYLLDDDEEQDHHHHHHH  480
 481 HRQEDLDEGAAEEEQDDEEESRYADDDEVDSKEAADKKQRRLKKKPSAINEQREPIIWSN  540
 541 HPYPGGCVSPGSSITSSFQCPTSMQQQQTFPVAGGSPNQQFQDNCSSSKATTPLSPFSAP  600
 601 ALSPTGFCCPKGSPVSGYESSSSTYSDSGSNYSLNLQLHAVYNDNLMYMQQQQQQQQQQH  660
 661 HLQHQQHLQRWLDQESLATARTSSVNRPLILVADTAPTNLTLVA
Interface Residues: 45, 80, 81, 82, 83, 85, 86
3D-footprint Homologues: 2glo_A
Binding Motifs: MA0213.1 syGGCGCy
brk TGGCGyY
Binding Sites: brk_1
brk_10
brk_11
brk_12
brk_2
brk_3
brk_4
brk_5
brk_6
brk_7
brk_8
brk_9
MA0213.1.1
MA0213.1.10
MA0213.1.2
MA0213.1.3
MA0213.1.4
MA0213.1.5
MA0213.1.6
MA0213.1.7
MA0213.1.8
MA0213.1.9
			
Publications: Zhang H, Levine M, Ashe H.L. Brinker is a sequence-specific transcriptional repressor in the Drosophila embryo. Genes & development 15:261-6 (2001). [Pubmed]


Bergman C.M, Carlson J.W, Celniker S.E. Drosophila DNase I footprint database: a systematic genome annotation of transcription factor binding sites in the fruitfly, Drosophila melanogaster. Bioinformatics (Oxford, England) 21:1747-9 (2005). [Pubmed]
Related annotations: PaperBLAST

	
			


			

				

				
				
				
				

			

			

		

	
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These data are available AS IS and at your own risk. The EEAD/CSIC do not give any representation or warranty nor assume any liability or responsibility for the data nor the results posted (whether as to their accuracy, completeness, quality or otherwise). Access to these data is available free of charge for ordinary use in the course of research. Downloaded data have CC-BY-NC-SA license. FootprintDB is also available at RSAT::Plants, part of the INB/ELIXIR-ES resources portfolio.