Transcription Factor

Accessions: Atoh1_DBD (HumanTF 1.0), T015240_1.02 (CISBP 1.02), ATOH1_MOUSE (HOCOMOCO 10), P48985 (JASPAR 2024)
Names: Atoh1, ATOH1_MOUSE, Helix-loop-helix protein mATH-1, mATH1, Protein atonal homolog 1, T015240_1.02;, Atonal bHLH transcription factor 1, Transcription factor Atoh1
Organisms: Mus musculus
Libraries: HumanTF 1.0 1, CISBP 1.02 2, HOCOMOCO 10 3, JASPAR 2024 4
1 Jolma A, Yan J, Whitington T, Toivonen J, Nitta KR, Rastas P, Morgunova E, Enge M, Taipale M, Wei G, Palin K, Vaquerizas JM, Vincentelli R, Luscombe NM, Hughes TR, Lemaire P, Ukkonen E, Kivioja T, Taipale J. DNA-Binding Specificities of Human Transcription Factors. Cell. 2013 Jan 17;152(1-2):327-39. [Pubmed]
2 Weirauch MT, Yang A, Albu M, Cote AG, Montenegro-Montero A, Drewe P, Najafabadi HS, Lambert SA, Mann I, Cook K, Zheng H, Goity A, van Bakel H, Lozano JC, Galli M, Lewsey MG, Huang E, Mukherjee T, Chen X, Reece-Hoyes JS, Govindarajan S, Shaulsky G, et al. Determination and inference of eukaryotic transcription factor sequence specificity. Cell. 2014 Sep 11;158(6):1431-43. doi: 10.1016/j.cell.2014.08.009. [Pubmed]
3 Kulakovskiy IV, Vorontsov IE, Yevshin IS, Soboleva AV, Kasianov AS, Ashoor H, Ba-Alawi W, Bajic VB, Medvedeva YA, Kolpakov FA, Makeev VJ. HOCOMOCO: expansion and enhancement of the collection of transcription factor binding sites models. Nucleic Acids Res : (2016). [Pubmed]
4 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed]
Notes: Ensembl ID: ENSMUSG00000073043; DNA-binding domain sequence; TF family: bHLH; Clone source: Hughes lab., experiment type:PBM, family:bHLH
Length: 351
Pfam Domains: 157-208 Helix-loop-helix DNA-binding domain
Sequence:
(in bold interface residues)
1 MSRLLHAEEWAEVKELGDHHRHPQPHHVPPLTPQPPATLQARDLPVYPAELSLLDSTDPR 60
61 AWLTPTLQGLCTARAAQYLLHSPELGASEAAAPRDEADSQGELVRRSGCGGLSKSPGPVK 120
121 VREQLCKLKGGVVVDELGCSRQRAPSSKQVNGVQKQRRLAANARERRRMHGLNHAFDQLR 180
181 NVIPSFNNDKKLSKYETLQMAQIYINALSELLQTPNVGEQPPPPTASCKNDHHHLRTASS 240
241 YEGGAGASAVAGAQPAPGGGPRPTPPGPCRTRFSGPASSGGYSVQLDALHFPAFEDRALT 300
301 AMMAQKDLSPSLPGGILQPVQEDNSKTSPRSHRSDGEFSPHSHYSDSDEAS
Interface Residues: 158, 160, 161, 162, 164, 165, 166, 168, 169, 192, 194
3D-footprint Homologues: 2ypa_A, 7z5k_B, 1an4_A, 6od3_F, 7ssa_L, 5i50_B, 4h10_A, 6g1l_A, 2ypa_B, 2ql2_A, 2ql2_D, 8osl_P, 5eyo_A, 5gnj_I
Binding Motifs: Atoh1_DBD / MA0461.2 rmCATATGky
MA0461.1 CAGmTGGy
M0224_1.02 rmCATATGtt
ATOH1_MOUSE.H10MO.C|M01017 rrCAGmTGGya
MA1467.2 rvCAGATGGym
MA0461.3 rmCATATG
MA1467.3 CAGATGG
Binding Sites: MA0461.1.1
MA0461.1.10
MA0461.1.11
MA0461.1.12
MA0461.1.13
MA0461.1.14
MA0461.1.15
MA0461.1.16
MA0461.1.17
MA0461.1.18
MA0461.1.19
MA0461.1.2
MA0461.1.20
MA0461.1.3
MA0461.1.4
MA0461.1.5
MA0461.1.6
MA0461.1.7
MA0461.1.8
MA0461.1.9
MA1467.2.1
MA1467.2.10 / MA1467.2.7
MA1467.2.11 / MA1467.2.8
MA1467.2.12 / MA1467.2.9
MA1467.2.10 / MA1467.2.13
MA1467.2.11 / MA1467.2.14 / MA1467.2.18
MA1467.2.12 / MA1467.2.15
MA1467.2.13 / MA1467.2.16
MA1467.2.14 / MA1467.2.17
MA1467.2.15 / MA1467.2.18
MA1467.2.16 / MA1467.2.19
MA1467.2.2
MA1467.2.17 / MA1467.2.20
MA1467.2.3
MA1467.2.4
MA1467.2.4 / MA1467.2.5
MA1467.2.5 / MA1467.2.6
MA1467.2.7
MA1467.2.6 / MA1467.2.8
MA1467.2.9
MA1467.2.19
MA1467.2.20
MA1467.3.1 / MA1467.3.10 / MA1467.3.11 / MA1467.3.12 / MA1467.3.14 / MA1467.3.15 / MA1467.3.16 / MA1467.3.17 / MA1467.3.2 / MA1467.3.20 / MA1467.3.5 / MA1467.3.6 / MA1467.3.8
MA1467.3.13 / MA1467.3.18 / MA1467.3.3
MA1467.3.19
MA1467.3.4
MA1467.3.7
MA1467.3.9
Publications: Jolma A, Yan J, Whitington T, Toivonen J, Nitta KR, Rastas P, Morgunova E, Enge M, Taipale M, Wei G, Palin K, Vaquerizas JM, Vincentelli R, Luscombe NM, Hughes TR, Lemaire P, Ukkonen E, Kivioja T, Taipale J. DNA-Binding Specificities of Human Transcription Factors. Cell. 2013 Jan 17;152(1-2):327-39. [Pubmed]

Lai H.C, Klisch T.J, Roberts R, Zoghbi H.Y, Johnson J.E. In vivo neuronal subtype-specific targets of Atoh1 (Math1) in dorsal spinal cord. The Journal of neuroscience : the official journal of the Society for Neuroscience 31:10859-71 (2011). [Pubmed]

Klisch TJ, Xi Y, Flora A, Wang L, Li W, Zoghbi HY. In vivo Atoh1 targetome reveals how a proneural transcription factor regulates cerebellar development. Proc Natl Acad Sci U S A 108:3288-93 (2011). [Pubmed]

Masuda M, Pak K, Chavez E, Ryan AF. TFE2 and GATA3 enhance induction of POU4F3 and myosin VIIa positive cells in nonsensory cochlear epithelium by ATOH1. Dev Biol 372:68-80 (2012). [Pubmed]
Related annotations: PaperBLAST

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